Lectins with Anti-HIV Activity: A Review

Akkouh, Ouafae; Ng, Tzi Bun; Singh, Senjam Sunil; Yin, Cuiming; Dan, Xiuli; Chan, Yau Sang; Pan, Wenliang; Cheung, Randy Chi Fai

doi:10.3390/molecules20010648

Cited by 98 publications

(80 citation statements)

References 111 publications

(113 reference statements)

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“…Lectins have been developed widely as probes to investigate cell surface structure and functions; they have also found applications as antiviral drugs and in the delivery of chemotherapeutic agents. A number of lectins capable of binding the high-mannose glycans commonly found in the surface of the envelope glycoproteins are currently under study to be used as microbicides [7,8]. Some of the most promising antiviral lectins include griffithsin (GRFT), cyanovirin (CV-N) and banana lectin (BanLec).…”

Section: Introductionmentioning

confidence: 99%

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

Lusvarghi

Bewley

2016

Viruses

119

115

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Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. The potential to inhibit other viruses as well as parasites has also been demonstrated. Griffithsin’s antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. Here, we review structural and biochemical studies that established mode of action and facilitated construction of GRFT analogs, mechanisms that may lead to resistance, and in vitro and pre-clinical results that support the therapeutic potential of this lectin.

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Section: Introductionmentioning

confidence: 99%

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

Lusvarghi

Bewley

2016

Viruses

119

115

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“…30 The World Health Organization (WHO) predicts that in the next few years more than 37 million people will be infected by HIV. 31 The HIV surface glycoprotein gp120 is one of the most heavily glycosylated proteins known so far, and its molecular weight consists of ∼50% of glycans. At the surface of the virus, the glycosylated glycoproteins gp120 and gp41 are imbedded in, and part of, the viral envelope at the start of the infection.…”

Section: Discussionmentioning

confidence: 99%

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity

et al. 2019

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Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: Canavalia brasiliensis (ConBr), C. maritima (ConM), Dioclea lasiocarpa (DLasiL) and D. sclerocarpa (DSclerL), and algae Amansia multifida (AML), Bryothamniom seaforthii (BSL), Hypnea musciformis (HML), Meristiella echinocarpa (MEL) and Solieria filiformis (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC 50 values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC 50 of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC 50 values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC 50 values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential. 390 | Med. Chem. Commun., 2019, 10, 390-398 This journal is

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“…There is evidence that lectins found in green bananas could provide a potential treatment for HIV patients and other viral infections such as, Ebola and hepatitis [26][27][28]. Other parts of the banana plant also have potential use in medical foods.…”

Section: Green Bananas and Health Benefitsmentioning

confidence: 99%

Let’s Go Bananas! Green Bananas and their Health Benefits

Apostolopoulos

Antonipillai

Tangalakis

et al. 2017

Prilozi

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Bananas have enormous health benefits as a food for both animals and humans. They have been used as a complimentary medicine to treat pathological conditions since ancient times. Recently, there has been increased interest in the scientific validity of the beneficial effects of bananas in alleviating and treating disease conditions including, ulcers, infections, diabetes, diarrhea, colitis and blood pressure. Herein, we write on the potential therapeutic and functional benefits of certain species of bananas when consumed green as well as considering the properties of extracts from the non-fruit parts of the plant. We conclude that green bananas appear to deliver an array of health and therapeutic benefits

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Lectins with Anti-HIV Activity: A Review

Cited by 98 publications

References 111 publications

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity

Let’s Go Bananas! Green Bananas and their Health Benefits

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