Lectins-the promising cancer therapeutics

Lavanya, V.; Adil, A A Mohamed; Ahmed, Naseem; Jamal, Shazia

doi:10.4103/2395-4469.145348

Cited by 8 publications

(2 citation statements)

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“…45) Vast amount of studies have been carried out with the aim to clarify the specific molecular mechanisms or clinical benefits of plant lectins. 17,46) In addition, as a T cell mitogen in vivo, plant lectins killed cells by stimulating immune system. 47) An immune memory would be generated after plant lectin-induced eradication, therefore resisting to the same genotypic tumor.…”

Section: Via This Model Is Plant Lectin a Promising Anti-cancer Drugmentioning

confidence: 99%

A Novel Molecular Model of Plant Lectin-Induced Programmed Cell Death in Cancer

Shi

Tang

et al. 2017

Biological & Pharmaceutical Bulletin

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Section: Via This Model Is Plant Lectin a Promising Anti-cancer Drugmentioning

confidence: 99%

A Novel Molecular Model of Plant Lectin-Induced Programmed Cell Death in Cancer

Shi

Tang

et al. 2017

Biological & Pharmaceutical Bulletin

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“…The lectins are suggested to be used in the anti-tumor drugs development as they have minimum side effects. According to few recent researches [14]- [17], for impediment of the progression of tumors, many lectins are used as therapeutic agents which outcomes apoptosis and agglutination of cancer cells. Nagaimo lectin is believed to be helpful in the treatment of breast cancer [18].…”

Section: Introductionmentioning

confidence: 99%

CanLect-Pred: A Cancer Therapeutics Tool for Prediction of Target Cancerlectins Using Experiential Annotated Proteomic Sequences

Butt

Khan

2020

IEEE Access

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Cancerlectins are significantly important group of lectins that have an inhibitory effect on cancer cells with respect to their growth. They have a vital role in various tumor cell interactions like adhesion, growth, metastasis, differentiation and mainly in cellular infection. The investigations associated with cancerlectins are applicable to relevant studies in laboratories, diagnostics and therapy in clinical applications, and drug discoveries in targeting cancers. Prediction of cancerlectins is considered a helpful task due to the fact that they are specifically useful in dissecting cancers. Although, several Bioinformatics tools have been developed to predict cancerlectins, however, the need for improvement in the quality of its prediction model requires enhancements in the annotation and determination process of cancerlectins. In this study, a new model is proposed that builds on statistical moments based features to distinguish cancerlectins from non-cancerlectins. The currently proposed model achieved an accuracy of 88.36% using jackknife test which is better than current state-of-the-art models. These outcomes suggest that the use of statistical moments could bear more effective and efficient results. For the accessibility of the scientific community, a user-friendly web server has been developed which will associate the researchers in medical science. Web server is freely accessible at https://www.biopred.org/canlect. INDEX TERMS Cancerlectins, Hahn moments, lectins, moment invariants, PRIM.

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