Lectin Receptors in the Human Cornea

Holmes, Marlee J.; Mannis, Mark J.; Lund, Judy; Jacobs, Lucien R.

doi:10.1097/00003226-198501000-00007

Cited by 17 publications

(9 citation statements)

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“…A number of investigators have studied lectin receptors of human corneas (Bonvicini et al 1983;Ahmed & Rahi 1985;Holmes et al 1986;Panjwani et al 1986b;. These studies have shown that the human corneal stroma contains receptors for Concanavalin A (ConA), Wheat germ agglutinin (WGA) and Ricunus comminis agglutinin I (RCA), whereas human corneal epithelium contains receptors for ConA, WGA and SBA.…”

Section: Species-specific Differences In the Carbohydrates Of Normal mentioning

confidence: 99%

Lectin receptors of normal and dystrophic corneas

Panjwani

Baum

1989

Acta Ophthalmologica

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In recent years, our laboratory has used lectins to detect carbohydrate-related abnormalities in dystrophic corneas and species-specific differences in the carbohydrates of normal corneas. These studies have: 1) demonstrated that abnormal glycoconjugates are present in corneas with macular and lattice dystrophy, 2) provided additional means of differentiating corneas with macular, lattice and granular dystrophy, 3) demonstrated that distinct species-specific differences are present in the glycoconjugates of normal corneas and 4) provided guidelines for the selection of an animal model for the study of corneal glycoconjugates.

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Section: Species-specific Differences In the Carbohydrates Of Normal mentioning

confidence: 99%

Lectin receptors of normal and dystrophic corneas

Panjwani

Baum

1989

Acta Ophthalmologica

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“…7 Lectins, at light microscopal level, investigate normal cornea in a variety of species. [8][9][10][11][12] In addition, by using this technique, changes in patterns of glycosylation have been observed in wounded and dystrophic corneas. 6,[13][14][15][16][17] Also, they determine the distribution of carbohydrate residues on photoreceptor cell surfaces.…”

Section: Introductionmentioning

confidence: 99%

Lectin binding in normal donkey eyeball

Aly

2013

Vet Sci Develop

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In the present study, the distribution of various sugar residues in the eyeball tissues of sexually mature donkey was examined by employing fluorescein isothiocyanate-conjugated lectins. Our results revealed the presence of mannose (labeled by lectins ConA), galactose (labeled by PNA, GSAI, ECA), GalNAc (labeled by SBA, VVA), and GlcNAc (labeled by WGA) residues in the donkey ocular tissues. The epithelium and stroma of the ocular tissues were labeled with mannose (ConA) and GlcNAc (WGA) binding lectins. Binding sites for WGA and PNA to the rod and cone cells of the retina were evident. The lectins Con A, WGA and GSAI are bound strongly to the endothelium of blood vessels and to smooth muscle cells of the iris. In conclusion, the findings of the present study clearly indicate that the donkey eyeball contains a wide range of glycoconjugates (bearing mannosyl, galactosyl and glucosly residues), and it lacks fucosyl residues.

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“…Refinements in the structural selectivity within mapping the presence of glycans were next achieved by introducing plant lectins for this purpose. These probes enabled determining spatially distinct distribution patterns and also nonrandom shifts in the glycomic profile after wounding (for examples, please see [3][4][5][6][7][8]). Lectin binding to differentially expressed cell surface glycans even made purification of cone photoreceptors possible, and this capacity, combined with prolonged retention of these proteins at the site of application, encouraged to consider testing plant agglutinins as an ocular drug delivery system [9][10][11].…”

Section: Introductionmentioning

confidence: 99%