Leclercia adecarboxylata, a rare cause of soft tissue infections in immunocompromised patients, case report and review of the literatura

Abstract

Leclercia adecarboxylata is a member of the Enterobacteriaceae family that has been isolated from several environmental and animal specimens, however it rarely causes diseases in human beings. It has natural resistance to several antibiotics, and has shown the ability to harbor and produce enzymes capable of hydrolyzing most of the antibiotics used in daily clinical practice, making its treatment a challenge when a strain with such characteristics causes disease. Here we report the first known case of infection by Leclercia adecarboxylata after a trauma with plant material, in a 69-year-old male patient, with poorly controlled Diabetes Mellitus type 2.Leclercia adecarboxylata, una causa rara de infección de tejidos blandos en pacientes inmunocomprometidos, reporte de caso y revisión de la literatura ResumenLeclercia adecarboxylata es un miembro de la familia Enterobacteriaceae que ha sido aislada tanto de muestras de animales como medioambientales, sin embargo raramente produce enfermedad en seres humanos. Tiene resistencia natural a varios antibióticos y se ha encontrado que tiene enzimas capaces de hidrolizar la mayoría de los antibióticos utilizados en la práctica clínica, lo cual hace un verdadero tratar una infección por este microorganismo en humanos. Aquí reportamos el primer caso de infección por Leclercia adecarboxylata luego de un trauma con material vegetal, en un paciente de 69 años y con una diabetes tipo 2, mal controlada.

Leclercia adecarboxylata Bacteremia without a Focus in a Non-Immunosuppressed Patient

“…In the literature, patients with L. adecarboxylata infection usually also have severe immunosuppression, for example, through the use of immunomodulators or chemotherapy [ 7 , 22 , 23 ]. On the other hand, few cases with diabetes as the only risk factor had skin and soft tissue infection [ 24 , 25 ]. Our patient had a PICC line for a few days, which could have been the source; however, only a peripheral blood culture was positive, contradicting this theory.…”

Osteomyelitis and septic arthritis from rare pathogen leclercia adecarboxylata: A case study

“…1,3 However, increasing resistance to these antibiotic agents has been reported in the literature. 4,5 L. adecarboxylata has a very similar microbiological appearance to Escherichia coli, a common microbial pathogen. It has been theorized that L. adecarboxylata infections have been underreported due to the similarities with E. coli.…”

Catheter-Related ESBL-Producing Leclercia adecarboxylata Septicemia in Hemodialysis Patient: An Emerging Pathogen?

“…However, a cumulative report of human infections by L. adecarboxylata mostly in immunocompromised patients suggested that the organism is an opportunistic bacterium and the infections caused by it are underestimated. It has been reported to cause septicemia [5], wound infection [6,7], urinary tract infection [8,9], posttraumatic polymicrobial infection [10], soft tissue infection [11], and peritonitis [12]. e majority of clinical isolates of L. adecarboxylata were susceptible to commonly used antibiotics [4], and multidrug-resistant isolates have rarely been reported [8].…”