Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo

The Effect of Am-80, a Synthetic Retinoid, on Spinal Cord Injury-Induced Motor Dysfunction in Rats

“…The room had a 12 h light/dark cycle. The study protocol was approved by the An- Spinal Cord Injury and Drug Treatment Impact injury of the spinal cord was induced by using the weight-drop device developed at New York University (NYU impact model), according to the method described by Takenaga et al 26,27) and Kitagawa et al 28) Adult female SD rats weighing 210-230 g were anesthetized and dorsal laminectomy was performed at the T 10 level, after which a 10 g weight was dropped onto the spinal cord from a height of 25 mm.…”

Cell therapy for spinal cord regeneration

“…A more recent study showed that mouse ESCs pretreated with a lecithinized brain derived neurotrophic factor (BDNF) implanted 9 days after T9/10 contusion injury showed better differentiation and promoted increased functional recovery afterwards, as assessed by BBB compared to cells treated with normal BDNF, demonstrating the influence of growth factor treatments on ESC differentiation [38]. Mouse ESCs predifferentiated using the 4−/4+ protocol were implanted after 7 days into a chronic pain SCI model that consisted of repeated microinjections of quisqualic acid between T13 and L1 [39].…”

Meta-coexpression conservation analysis of microarray data: a "subset" approach provides insight into brain-derived neurotrophic factor regulation

“…Thyroid hormone receptor alpha (THRA) induces expression of BDNF receptor NTRK2 [ 38 ]. Finally, expression of such genes like EGR1 [ 39 ], MBP [ 40 ], NEFL [ 41 ], NPTX1 [ 42 ], NTRK2 , SERPINE1 [ 43 ], SCG2 [ 44 ], SNCA [ 45 ] and TCF4 (also known as ITF2 ) [ 46 ] is known to be regulated by BDNF signaling. CCND2 , DUSP1 , DUSP6 , EGR1 and RGS4 gene expression is altered in cortical GABA neurons in the absence of BDNF [ 47 ].…”