Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging

Raut, Sushil; Bhadoriya, Santosh Singh; Uplanchiwar, Vaibhav; Mishra, Vijay; Gahane, Avinash; Jain, Sunil K.

doi:10.1016/j.apsb.2011.12.005

Cited by 106 publications

(76 citation statements)

References 55 publications

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“…28) In addition, the polar nature of the polyphenols is drawback for a delivery through the skin barrier, and 29) consisting of HMHEC and lecithin 30) of more than 95%, 31) was therefore prepared in this present study as a delivery system in a comparison with a commercial liposome ( Table 4). The content of cellulose polymer was increased to improve steric stabilization, providing more surface coverage area and higher excluded volume limiting the nucleation process of the liposome, 32) and loaded with 50 mg/mL the Salak plum peel EtOAc fraction.…”

Section: Preparation and Stability Of The Salak Plum Peel Etoac Fractmentioning

confidence: 99%

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Kanlayavattanakul¹,

Lourith²,

Ospondpant³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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The antioxidant activities of Salak plum (Salacca edulis) peel extracts were assessed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 0 -azino-bis(3-ethylbenzothaiazoline)-6-sulfonic acid (ABTS), and ferric reducing ability of plasma (FRAP) assays. The ethyl acetate (EtOAc) fraction was the most potent (DPPH IC50 ¼ 2:932 AE 0:030 g/mL, ABTS IC50 ¼ 7:933 AE 0:049 g/mL, FRAP EC ¼ 7;844:44 AE 40:734). Chlorogenic acid was detected as the marker (1:400 AE 0:102 g/kg). The EtOAc fraction was non-cytotoxic in vero and normal human fibroblast (NHF) cells. It exhibited cellular oxidative prevention and damage treatment at 5-40 g/mL in NHF cells. Salak plum peel loaded liposome consisting of lecithin and hydrophobically modified hydroxyethylcellulose (HMHEC) was developed and found stable with adequate entrapment efficacy. Thus Salak plum peel was highlighted as a potential ecological antioxidant for health promotion aspects, and for cosmetics.

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Section: Preparation and Stability Of The Salak Plum Peel Etoac Fractmentioning

confidence: 99%

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Kanlayavattanakul¹,

Lourith²,

Ospondpant³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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show abstract

“…One such example is micellar lecithin organogel which is reported to form self-assembled cylindrical to rod-shaped micelles that can carry both lipophilic and hydrophilic drugs assuring deep skin penetration and is investigated for variety of applications including skin lighteners, antifungal, anticancer, vitamin, peptide, antioxidant delivery, etc. It is of prime importance from anti-ageing perspective as lecithin itself acts as proteaseactivated receptor 2 inhibitor asserting protection against UV-induced skin ageing and thus acts synergistically with anti-ageing bioactives [ 80 ].…”

Section: Anti-ageing Nanotherapeuticsmentioning

confidence: 99%

Topical Nanointerventions for Therapeutic and Cosmeceutical Applications

Patravale

Desai

2013

Advances in Delivery Science and Technology

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“…So far, many oil-based topical formulations were reported. [30] Groundnut oil is extensively used for edible purposes. From the 'test on extract' study, it was observed that the releasate of OG5-80, when applied to the cells in concentrations of 10% v/v of total media, showed no cytotoxicity.…”

Section: Skin Cell Compatibility Testmentioning

confidence: 99%

Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics

Singh

Yadav

Kulanthaivel

et al. 2016

Designed Monomers and Polymers

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There is a persistent demand for an efficient drug delivery system, suitable for the delivery of both hydrophilic and lipophilic drugs. This study explores groundnut oil-based emulsion gels for the above-mentioned application. On the basis of stability, two representative gels OG5-80 (low oil content) and OG7-45 (high oil content) were studied further. Analysis of microarchitecture by ESEM and confocal microscopy, in conjugation with fluorescence recovery after photobleaching, confirmed the conversion of the dispersion phase from oil-continuous (OG7-45) to bicontinuous (OG5-80) with increasing water proportion. The gels were viscoelastic with unique stress relaxation properties. Passive and active (iontophoretic) release kinetics of the drugs showed differential release patterns. Mathematical modeling elucidated composition-dependent temporal variation in the drug release and stress relaxation patterns. In vitro cell viability study, cell cycle analysis, and immunocytochemistry divulged compatibility of the gels to human skin cells (keratinocytes). Drugloaded gels were found active against B. subtilis and E. coli. Hence, groundnut oil-based emulsion gels can be an efficient and stable multimodal carrier system for the passive and the active delivery of both hydrophilic and lipophilic drugs.

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Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging

Cited by 106 publications

References 55 publications

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Topical Nanointerventions for Therapeutic and Cosmeceutical Applications

Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics

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