Lecithin Cholesterol Acyltransferase Deficiency Protects from Diet-Induced Insulin Resistance and Obesity—Novel Insights from Mouse Models

Ng, Dominic S.

doi:10.1016/b978-0-12-407766-9.00011-0

Cited by 5 publications

(1 citation statement)

References 43 publications

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“…PLTPs also play an important role in transferring diacylglycerol, alpha‐tocopherol, cerebroside, and lipopolysaccharides. However, plasma PLTP is not only a nonspecific lipid transfer protein; it was also been implicated in the pathogenesis of atherosclerosis and diabetes mellitus, and is involved in inflammatory responses and antioxidant defense . Plasma PLTP levels are elevated in patients with diabetes mellitus and obesity, and this protein is positively correlated with BMI, waist to hip circumference ratio, fasting blood glucose, plasma C‐peptide, and insulin resistance parameters .…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomics of umbilical vein blood plasma from normal and gestational diabetes mellitus patients reveals differentially expressed proteins associated with childhood obesity

Miao

Wang

et al. 2016

Proteomics Clinical Apps

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Purpose Offspring obesity is one of long‐term complications of gestational diabetes mellitus (GDM). The aim of this study is to identify proteins differentially expressed in the umbilical vein blood plasma, which could become markers for early diagnosis of childhood obesity. Experimental design Umbilical vein plasma samples were collected from 30 control and 30 GDM patients in 2007–2008 whose offspring were suffering from obesity at 6–7 years old. Multiplexed isobaric tandem mass tag labeling combined with LC–MS/MS was used to identify differentially expressed proteins. Ingenuity pathway analysis was performed to identify canonical pathways, biological functions, and networks of interacting proteins. Western blotting was used to verify the expression of three selected proteins. Results A total of 318 proteins were identified, of which 12 proteins were upregulated in GDM group while 24 downregulated. Lipid metabolism was the top category identified by ingenuity pathway analysis. Three randomly chosen proteins were validated by Western blotting, which were consistent with LC–MS. Conclusion There are significant differences of protein profile in the umbilical vein blood plasma between normal and GDM patients with obese offspring. The results indicate that a variety of proteins and biological mechanisms may contribute to childhood obesity.

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Section: Discussionmentioning

confidence: 99%