Leberzirrhose und Hyperöstrogenismus

Kley, H K; Wiegelmann, W.; Nieschlag, Eberhard; Krüskemper, H. L.

doi:10.1055/s-0028-1104260

Cited by 4 publications

(2 citation statements)

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“…Diese "präanalytische Sorgfalt zur Elimination von Störfaktoren" (l, 2, 3) scheint auch erforderlich zu sein, wenn man die vielen Möglichkei-ten einer Änderung der Molekülstruktur von Steroiden und ihrer Plasmabindung vermeiden will: Enzyme im Plasma sind nämlich in der Lage, Proteine abzubauen (4,5), Erythrocyten können Steroide binden (6) und metabolisieren (7,8,9); Lymphocyten und Granulocyten binden Steroidhormone durch intrazelluläre Rezeptoren (10), und es sind eine Vielzahl von Bakterien bekannt, die Steroide zu verän-dern vermögen (11,12). Dies gilt in noch stärkerem Maße, wenn man berücksichtigt, daß einige der am häufigsten gemessenen Steroidhormone an Plasmaproteine gebunden sind (13), die gegenüber Verän-derungen durch Enzyme, Temperatur oder Bakterien besonders empfindlich zu sein scheinen (4). Aus diesem Grunde ist es verwunderlich, daß bisher nur wenige Publikationen vorhanden sind (14,15,16) …”

Section: Einführungunclassified

Einfluß von Lagerung und Temperatur auf die Analyse von Steroiden in Plasma und Blut

Kley¹,

Rick²

1984

Clinical Chemistry and Laboratory Medicine

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Aus den Untersuchungen folgt, daß Steroide und ihre Plasmabindung in Blut oder Plasma gegenüber den meisten üblichen äußeren Einflüssen relativ stabil sind und auch aus weniger sorgfältig behandelten Proben (Postversänd) in der Regel noch ausreichend zuverlässig analysiert werden können. Influence of storage and temperature on steroid analysis in plasma and blood Summary:In the analysis of steroid Jiormones careful attention is usually paid to blood collection and plasma storage. However, the appropriate care of samples cannot always be assured in routine work with steroids. Therefore, the stäbility of Cortisol, aldosterone, 17-hydroxyprogesterone, testosterone, androstenedione, dehydroepiandrosteronesulphate, oestrone, oestradiol, sex hormone binding globulin (SHBG) and, the binding of testosterone and cortisol to plasma proteins in blood and plasma were studied before and after various handling prpcedures, Ten cycles of alternate freezing and thawing of plasma did not significantly affect the levels of the steroids or their plasma binding. The greatest differences, compared with controls, were seen for aldosterone (-6.2%) and oestradiol (-5.3%). Plasma storage at -28 °C was hardly superior to a 4 days storage at 4 °C (refrigera-

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Section: Einführungunclassified

Einfluß von Lagerung und Temperatur auf die Analyse von Steroiden in Plasma und Blut

Kley¹,

Rick²

1984

Clinical Chemistry and Laboratory Medicine

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“…Numerous studies have shown that several extrahepatic factors are involved in the alteration of steroid me¬ tabolism (Adlercreutz 1970;Kley et al 1976). Numerous studies have shown that several extrahepatic factors are involved in the alteration of steroid me¬ tabolism (Adlercreutz 1970;Kley et al 1976).…”

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Liver Cirrhosis and Oestrogen Metabolism – Perfusion Studies With Cirrhotic Rat Livers

Höller

Dengler

Fabricius

et al. 1979

Acta Endocrinologica

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1. Radioactive oestrone and oestradiol-17\g=b\ were perfused through normal and cirrhotic livers of rats. Liver cirrhosis had been induced by a combined application of carbon tetrachloride and azathioprine.2. The hepatic uptake of both oestrogens by cirrhotic livers was reduced; the uptake of oestrone was more affected than that of oestradiol-17\g=b\, 3. The pattern of oestrogen metabolites indicated a reduction of the sulphotransferase activity in cirrhotic livers. The activity of other enzymes of oestrogen metabolism were similar in normal and cirrhotic livers.4. The amount of oestrogen glucuronides excreted into the bile was significantly less in cirrhotic livers although the bile volume was larger in cirrhotic than in normal livers.5. The release of oestrogen metabolites into the circulating medium was considerably higher during perfusion of cirrhotic livers. From the findings presented here it is concluded that the turnover of oestrogens is slower in cirrhotic than in normal livers. Moreover, it may be speculated that the distribution volume of the oestrogen metabolites is smaller in rats with liver cirrhosis, due to a disturbed enterohepatic circulation. This results in higher oestrogen concentrations in extracellular fluids, thus supporting the concept of hyper-oestrogenism in liver cirrhosis.

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Untersuchungen �ber die Hypophysen-Testes-Funktion bei M�nnern mit chronischen Lebererkrankungen

Geisthövel

Mühlen

1978

Klin Wochenschr

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In 27 male patients (age 31--60 years) with chronic hepatic diseases--10 of which with alcohol-toxic cirrhosis (ACi), 10 with hepatitic cirrhosis (HCi) and 7 with chronic aggressive hepatitis (CHAH)--total testosterone (T) and total oestradiol-17 beta (E2) in plasma were determined before and after HCG i.m. as well as LH and FSH before and 30 min and 60 min after LH-RH i.v. T, E2, LH and FSH were evaluated by specific RIA. Basal T was significantly decreased in ACi in comparison to normals and to HCi and CHAH. The increase after stimulation with HCG was reduced in all patient groups. Mean E2 before stimulation was altered in none of the groups compared to controls. After HCG there was an inadequate response only in ACi. Before as well as after stimulation with LH-RH, LH and FSH were increased in all patient groups. Our results point to the following: In males with chronic hepatic failure a testes insufficiency often occurs, which may depend on the etiology and the stage of the liver disease. An additional pituitary insufficiency appears not to exist.

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Leberzirrhose und Hyperöstrogenismus

Cited by 4 publications

References 0 publications

Einfluß von Lagerung und Temperatur auf die Analyse von Steroiden in Plasma und Blut

Einfluß von Lagerung und Temperatur auf die Analyse von Steroiden in Plasma und Blut

Liver Cirrhosis and Oestrogen Metabolism – Perfusion Studies With Cirrhotic Rat Livers

Untersuchungen �ber die Hypophysen-Testes-Funktion bei M�nnern mit chronischen Lebererkrankungen

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