Leber und Gallenwege

Bolck, F.; Machnik, G

doi:10.1007/978-3-642-96410-7

Cited by 18 publications

(5 citation statements)

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“…Abnormal developments of the fetal venous system are rare and there is a large variation in these abnormalities. In the majority of cases, an abnormal course of veins due to missing obliteration of primitive veins or non‐development of new vessels and anastomoses are found 7,16 , 17 . The abnormality can either affect the umbilical, hepatic, portal or caval venous system alone, or there may be a combination of defects of the venous systems.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal diagnosis of abnormalities of the fetal venous system

Hofstaetter

Plath

Hansmann

2000

Ultrasound in Obstet & Gyne

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In a targeted fetal scan the course of the umbilical vein, ductus venosus, the portal and hepatic veins and inferior vena cava should be carefully examined using color Doppler. Any suspicious finding should be followed by a detailed assessment of the specificity of this abnormality taking into consideration the embryologic development of the fetal venous system together with the associated malformations.

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Section: Discussionmentioning

confidence: 99%

“…Abnormalities of the major body veins, the IVC and SVC, however, are often associated with major impairments of the development of the heart, the intestinal tract and body symmetry. These associated malformations are of great clinical importance 12,13 , 17 .…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of abnormalities of the fetal venous system

Hofstaetter

Plath

Hansmann

2000

Ultrasound in Obstet & Gyne

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“…KOO et a1 [56] assume chemical carcinogens to be important etiological factors in gallbladder carcinoma, with gallstones playing a supporting role in the sense of a syncarcinogenesis. Therefore the formation of gallbladder carcinoma is undoubtedly based on the result of an inter-action between a local malignant process and the whole organism [65].…”

Section: Pathogenesismentioning

confidence: 99%

Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature

Sons¹,

Borchard²,

Joel³

1985

Journal of Surgical Oncology

126

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From 1950 to 1982, 287 patients with cancer of the gallbladder were autopsied. The ratio of men to women was 1:3.7. The average age of women was 70 years; that of men was 69.5 years. Most tumors (67.7%) had grown by diffuse infiltration and one-third (32.3%) were polypous-exophytic. Fundus and collum of the gallbladder showed an equal frequency (24%) of tumor localisation. The percentage of all gallbladder malignomas that were adenocarcinomas of various differentiation was 84.6, and 10.9% were anaplastic carcinomas, the rest consisted of squamous cell carcinomas (3.7%) and 0.8% sarcomas. Metastases were found in 265 cases (92.3%). Tumorous infiltration, lymph node metastases, and visceral metastases are discussed. A cholelithiasis was found in 78.4%. The results are compared with the literature.

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“…It has been reported that CMV-specific owl eye cells can be detected in all organs by histology [1]. Endothelial and epithelial cells especially seem to be infected.…”

Section: Introductionmentioning

confidence: 94%

Cytomegalovirus-Induced Transendothelial Cell Migration

Scholz

Blaheta²,

Vogel³

et al. 1999

Intervirology

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A variety of cells such as leukocytes and tumor cells may adhere to endothelial cells and subsequently transmigrate into the solid tissue by involving specific intercellular molecular pathways. One important prerequisite for transendothelial migration is the loosening of endothelial cell-to-cell contact sites, which can be triggered by extravasating cells. Cytomegalovirus (CMV) has obviously evolved the ability not only to influence host cells floating in the blood stream to adhere to endothelial cells, but also to induce the formation of intercellular gaps within the endothelium, resulting in transendothelial migration. These features allow the virus to disseminate and evade the immune system. In coculture experiments with human endothelial monolayers and human CMV (HCMV)-infected neuroblastoma cells or leukocytes, changes in the integrity of the monolayer were observed and further analyzed on the molecular level. For example, HCMV may activate the integrin β1α5 (VLA-5) that triggers adhesion to endothelial cells with subsequent focal disruption of endothelial cell-to-cell connections. It is hypothesized that a Ca²⁺-independent pathway following VLA-5 binding disconnects the cadherin-catenin-actin complex within the endothelial cells. The loss of cadherin function causes the loss of contact to the neighboring endothelial cells and thus could represent an important mechanism in HCMV-induced cellular transendothelial migration and disruption of the endothelial integrity.

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Leber und Gallenwege

Cited by 18 publications

References 0 publications

Prenatal diagnosis of abnormalities of the fetal venous system

Prenatal diagnosis of abnormalities of the fetal venous system

Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature

Cytomegalovirus-Induced Transendothelial Cell Migration

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