LEBERʼs NEURORETINITIS IN A PATIENT WITH SEROLOGIC EVIDENCE OFBARTONELLA ELIZABETHAE

Hs, O'Halloran; Draud, K; Minix, M; Ak, Rivard; Pa, Pearson

doi:10.1097/00006982-199803000-00015

Cited by 51 publications

(21 citation statements)

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“…The only human isolate was made from a patient with endocarditis, 7 and serologic evidence suggests that infection with B. elizabethae may also be associated with Leber's neuroretinitis. 16 This high antibody prevalence suggests that this or related organisms are ubiquitous in the inner-city IDU environment, and that exposure is commonplace. The mechanisms by which Bartonella infections are acquired by IDUs is unknown.…”

Section: Discussionmentioning

confidence: 99%

Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.

Comer

Diaz²,

Vlahov³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. We tested serum samples collected in 1997 and 1998 from a cohort of 204 injection drug users (IDUs) recruited from Central and East Harlem, New York City, New York, for antibodies reactive with seven rickettsial or Bartonella spp. antigens. Rodent-associated Bartonella elizabethae and Rickettsia akari were the primary etiologic agents of interest. The testing panel also included Bartonella henselae, Bartonella quintana, Rickettsia prowazekii, Rickettsia rickettsii, and Rickettsia typhi. The highest prevalence of seroreactive serum samples (46%) was found with B. elizabethae antigens; 10% of the samples reacted with B. henselae antigens, while 2% reacted with B. quintana antigens. Reactivity to the latter two antigens was likely due to cross-reactivity with B. elizabethae antigens in most instances. Among the spotted fever group rickettsiae, 18 (9%) samples reacted with R. akari, including 10 samples (5%) that also reacted with R. rickettsii. Cross-adsorption studies demonstrated that most of the spotted fever group rickettsiae antibodies were due to R. akari infections. Among the typhus group rickettsiae, 5 samples reacted weakly to R. prowazekii antigens, and no samples reacted with R. typhi antigens. These findings suggest that Harlem IDUs are commonly exposed to two rodent-associated zoonotic agents. Further study of IDU populations may help elucidate transmission cycles of these agents in inner cities where higher levels of transmission occur.

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Section: Discussionmentioning

confidence: 99%

Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.

Comer

Diaz²,

Vlahov³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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“…Furthermore, 31% of 1 136 Swedish orienteers were seropositive for B. elizabethae [155]. Infections caused by B. elizabethae in humans have been associated with endocarditis and neuroretinitis [60,177]. However, such studies based only on serological data need to be confirmed by identification of this pathogen either by PCR methods or isolation.…”

Section: Rodent-borne Zoonotic Bartonellaementioning

confidence: 99%

Factors associated with the rapid emergence of zoonotic Bartonella infections

et al. 2005

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-The present manuscript reviews the factors associated with the emergence of these zoonotic pathogens, including better diagnostic tools and methods to identify these fastidious bacteria, host immunosuppression (caused by infectious agents, cancer, aging or induced by immunosuppressive drugs), the interaction of co-infection by several infectious agents that may enhanced the pathogenecity of these bacteria, increased outdoor activity leading to exposure to wildlife reservoirs or vectors, poverty and low income associated with infestation by various ectoparasites, such as body lice and finally the dispersal of Bartonellae around the world. Furthermore, a description of the main epidemiological and clinical features of zoonotic Bartonellae is given. Finally, the main means for diagnosis, treatment and prevention of these diseases are presented.

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“…In addition to animal hosts in close contact with humans such as cats, dogs, and cattle, rodents are one of the most important reservoirs. Many Bartonella species have been identified in rodents, and there is an increasing number of human and canine infections reportedly caused by rodent-borne Bartonella (Daly et al, 1993;O'Halloran et al, 1998;Kerkhoff et al, 1999;Welch et al, 1999;Kosoy et al, 2003;Serratrice et al, 2003;Fenollar et al, 2005). Bartonellae are transmitted by variety of bloodsucking arthropods; identified vectors include the sand fly (Lutzomyia verrucarum) as a vector for Bartonella bacilliformis (Alexander, 1995), the body louse (Pediculus humanus) for Bartonella quintana (Maurin and Raoult, 1996), and the cat flea (Ctenocephalides felis) for Bartonella henselae (Chomel et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic Analysis of Bartonella Detected in Rodent Fleas in Yunnan, China

Liu

et al. 2007

Journal of Wildlife Diseases

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ABSTRACT:Previous studies have demonstrated a diversity of Bartonella spp. in rodent populations in Yunnan Province, China. Although Bartonella spp. have been isolated from cat fleas and cattle ticks collected from their animal hosts, little is known about Bartonella carried by rodent fleas. In this study, Bartonella DNA was detected by polymerase chain reaction (PCR) in two of five species of rodent fleas. These included Xenopsylla cheopis and Ctenophthalmus lushuiensis, which were collected from Rattus tanezumi flavipectus and from the nests of voles, respectively, during 1997 from two sites in western Yunnan Province, China. Sequence analysis of the Bartonella citrate synthase gene (gltA) amplicons obtained from six of 65 grouped flea samples showed that Bartonella genetic variants were clustered in four groups. One from Xenopsylla cheopis was identical to Bartonella tribocorum, whereas the other three genotypes from Ctenophthalmus lushuiensis were related to the vole-associated Bartonella isolates and cat-associated Bartonella clarridgeiae. This is the first detection of this Bartonella variant from fleas in China. Therefore, further investigations are needed to clarify the distribution of Bartonella in rodents and their ectoparasites in China to define the role of these arthropods in the transmission routes of Bartonella.

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LEBERʼs NEURORETINITIS IN A PATIENT WITH SEROLOGIC EVIDENCE OFBARTONELLA ELIZABETHAE

Cited by 51 publications

References 0 publications

Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.

Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.

Factors associated with the rapid emergence of zoonotic Bartonella infections

Phylogenetic Analysis of Bartonella Detected in Rodent Fleas in Yunnan, China

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