Lebensmittelhygienische Betrachtungen zur östrogenen Mast von Schlachttieren

Engst, R.; Säuberlich, H.

doi:10.1002/food.19650090313

Cited by 2 publications

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“…In The Netherlands fattening of calves is an important part of beef production. Many authors claim that oestrogens are growth-promoting (ENGST and SAUBERLICH, 1965). According to legislative rules in The Netherlands issued in 1961 the administration of oestrogens to calves is prohibited.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the “Prostate test” in Checking the Administration of Oestrogens in the Calf1

Ruitenberg¹,

Kroes²,

Berkvens

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary The effect of various oestrogens was studied in male calves. The following oestrogens were used: diethylstilboestrol (in dosages of 20, 50 and 80 mg.), hexoestrol (80 and 160 mg.), dienoestrol (80 mg.) and oestradiol monobenzoate (80 mg.). The histological reaction of the prostate was studied in short term experiments (1–21 days after administration of the oestrogen) and long term experiments (8, 9, and 12 weeks after administration of the oestrogen). The oestrogens were injected both intramuscularly and subcutaneously. In the prostates of all treated animals, hyperplastic and metaplastic changes were observed. These changes were not influenced by the simultaneous application of a weak androgen (Laurabolin). Besides the parenteral administration the influence of orally administered diethylstilboestrol on the prostate was studied. Again the prostate reacted with hyperplasia and metaplasia. Zusammenfassung Auswertung des “Prostata‐Tests” beim Nachweis der Oestrogenapplikation an Kälbern Bei Stierkälbern wurde die Wirkung verschiedener Oestrogene untersucht. Folgende Oestrogene wurden geprüft: Diäthylstilböstrol (Dosis: 20, 50, 80 mg), Hexöstrol (80, 160 mg), Dienöstrol (80 mg) und Oestradiolmonobenzoat (80 mg). Die histologischen Reaktionen der Prostata wurden in kurzdauernden (1–21 Tage) sowie langdauernden (8, 9 und 12 Wochen) Experimenten studiert. Die Oestrogene wurden sowohl intramuskulär als auch subkutan appliziert. Bei allen Tieren traten hyperplastische und metaplastische Veränderungen auf. Diese Veränderungen wurden durch die gleichzeitige Verabreichung eines schwachen Androgens (Laurabolin) nicht beeinflußt. Außer der parenteralen Verabreichung wurde auch der Einfluß der oralen Applikation von Diäthylstilböstrol auf die Prostata geprüft. Auch in diesen Versuchen reagierte die Prostata mit einer Hyperplasie und Metaplasie. Résumé Evaluation du après administration d'oestrogènes chez le veau On étudie les effets de différents oestrogènes sur des veaux mâles. On emploie les oestrogènes suivants: diéthylstilboestrol (en doses de 20, 50 et 80 mg), hexoestrol (80 et 160 mg), diènoestrol (80 mg) et le monobenzoate d'oestradiol (80 mg). On suit la réaction histologique de la prostate dans des expériences à court terme (1–21 jours après administration de l'oestrogène) et à long terme (8, 9 et 12 semaines après administration de l'oestrogène). On injecte les oestrogènes par voie intramusculaire et sous‐cutanée. On observe des modifications hyperplastiques et métaplasiques dans la prostate de tous les animaux traités. Ces modifications ne sont pas influencées par l'application simultanée d'un androgène faible (Laurabolin). Après étude des effets de l'administration parentérale, on étudie l'influence du diethylstilboestrol administré per os sur la prostate. La prostate réagit également par und hyperplasie et une métaplasie. Resumen Evaluación de la en la búsqueda de la administración de estrógenos a terneros Estudióse el efecto de varios estrógenos en terneros. Se us...

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Section: Introductionmentioning

confidence: 99%

Evaluation of the “Prostate test” in Checking the Administration of Oestrogens in the Calf1

Ruitenberg¹,

Kroes²,

Berkvens

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Detection of illegal estrogen administration through immunohistochemical markers in the bovine prostate

et al. 1999

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Pesq. Vet. Bras. 19(3/4):133-138, jul./dez. 1999 133 RESUMO. [Verificação da administração ilegal de estróge-nos através de marcadores imunohistoquímicos na prós-tata de bovinos.] A imunodeteccão de marcadores celulares foi avaliada em amostras prostáticas de bovinos com hiperplasia ou hiperplasia-metaplasia epiteliais, induzidas por estróge-nos administrados ilegalmente e em próstatas de bovinos inoculados com dietilstilbestrol (DES). A técnica de recuperacão antigênica permitiu o uso de tecidos fixados em formalina, por longos períodos. Foram utilizados os anticorpos monoclonais K8.12, anti-vimentina e anti-desmina para determinação de células basais coradas/epitélio hiperplásico-metaplásico, células do estroma e células musculares, respectivamente. As alterações tissulares observadas nos casos de campo e nos experimentais foram semelhantes, através do que se concluiu que houve administração ilegal de estrógenos. O teste imunohistoquímico com esses marca-dores específicos foi útil ao exame histológico da próstata, uma vez que a análise das imagens permite maior e melhor quantificação das alterações observadas. Os testes bioquí-micos, entretanto, são necessários para uma avaliação mais precisa. TERMOS DE INDEXAÇÃO:Próstata bovina, marcadores de celulares, imunohistoquímica, estrógenos. INTRODUCTIONThe use of hormonal anabolics in the fattening of cattle can lead to an increase of about 10-20% of its body weight by mainly affecting the musculature (Engst & Sauerlich 1965, McMartin et al. 1978. The most frequently used drugs are diethylstilbestrol (DES) or DES esters such as DES dipropionate (DES-DP) due to their efficacy, price, availability and stability (Jansen et al. 1989). DES has been banned from beef production primarily because of health risks resulting on account of its carcinogenic and teratogenic properties (Herbst et al. 1974, McMartin et al. 1978. Nevertheless, illegal DES administration occurs and it is a matter of concern in many countries (Epstein 1990).Hyperplasia and squamous metaplasia of the prostatic glandular epithelium have been considered as DES-induced The immunodetection of diverse cell markers was evaluated in prostatic samples from bullocks, and bullocks showing epithelial hyperplasia-metaplasia, with oestrogen-induced changes, and in experimental samples from bullocks inoculated with dietylstilbestrol (DES). Antigen-retrieval procedures allowed the use of tissues that had been fixed in formalin for long periods. Three tissue markers were chosen for the study: cytokeratins 13 and 16, vimentin and desmin. Monoclonal antibody K8.12 (specific for cytokeratins 13 and 16) stained basal cells and hyperplastic-metaplastic epithelium; monoclonal antivimentin, and desmin, allowed the definition of fibromuscular changes.

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Lebensmittelhygienische Betrachtungen zur östrogenen Mast von Schlachttieren

Cited by 2 publications

References 67 publications

Evaluation of the “Prostate test” in Checking the Administration of Oestrogens in the Calf1

Evaluation of the “Prostate test” in Checking the Administration of Oestrogens in the Calf1

Detection of illegal estrogen administration through immunohistochemical markers in the bovine prostate

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