Learning spatial working and reference memory tasks induces region-specific increases in the expression of the gene encoding syntaxin 1B

Davis, Scott; Rodger, Jennifer; Hicks, Albert J.; Mallet, J.; Laroche, Serge

doi:10.1016/s0928-4257(97)87934-x

Cited by 1 publication

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“…Despite major progress in understanding the molecular events governing exocytosis, the mechanisms controlling the expression of the main players in this process have been poorly explored. Variations in the level of key components of the secretory apparatus have been associated with various physiological and pathological conditions, including learning, ischaemia, schizophrenia and diabetes mellitus [4][5][6][7][8]. However, in most cases, the molecular determinants responsible for the observed changes have not been identified.…”

Section: Mechanisms Controlling the Expression Of The Components Of Tmentioning

confidence: 99%

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

Abderrahmani

Plaisance

Lovis

et al. 2006

Biochemical Society Transactions

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The last decade has witnessed spectacular progress in the identification of the protein apparatus required for exocytosis of neurotransmitters, peptide hormones and other bioactive products. In striking contrast, our knowledge of the mechanisms determining the expression of the components of the secretory machinery has remained rudimentary. Since modifications in secretory functions are associated with several physiological processes and contribute to the development of human pathologies, a better knowledge of the control of the expression of the genes involved in exocytosis is urgently needed. Recent studies have led to the identification of transcription factors and other regulatory molecules such as microRNAs that modulate the cellular level of key controllers of the exocytotic process. These findings furnish a new perspective for understanding how secretory functions can adapt to normal physiological conditions and shed light on the mechanisms involved in the development of important human diseases such as diabetes mellitus characterized by defective release of bioactive compounds.

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Section: Mechanisms Controlling the Expression Of The Components Of Tmentioning

confidence: 99%

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

Abderrahmani

Plaisance

Lovis

et al. 2006

Biochemical Society Transactions

View full text Add to dashboard Cite

show abstract

Learning spatial working and reference memory tasks induces region-specific increases in the expression of the gene encoding syntaxin 1B

Cited by 1 publication

References 0 publications

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

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