Learning-related changes in brain activity following errors and performance feedback in schizophrenia

Morris, Sarah; Heerey, Erin A.; Gold, James M.; Holroyd, Clay B.

doi:10.1016/j.schres.2007.08.027

Cited by 108 publications

(103 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of Experiment 2 confirmed our hypothesis that fERN amplitude would depend on reward probability when participants are required to learn by trial and error to associate the probabilities with visual images of objects, as was found in previous experiments (e.g., Eppinger et al, 2008;Morris et al, 2008;Nieuwenhuis, Nielen et al, 2005;Nieuwenhuis et al, 2002). Nevertheless, as with Experiment 1, the effect size associated with this finding was modest ( 2 p 0.24).…”

Section: Methodssupporting

confidence: 89%

“…This hypothesis was predicated on the observation that in several previous fERN experiments, participants learned by trial and error how to respond to visual images of arbitrary objects (see, e.g., Eppinger et al, 2008;Morris et al, 2008;Nieuwenhuis, Nielen et al, 2005;Nieuwenhuis et al, 2002). We speculated that fERN amplitude would be modulated by reward probability when participants learn to associate reward probabilities with predictive cues, as opposed to when the probabilities are explicitly indicated by the predictive cues on the start of each trial (as in Experiment 1; Figure 1, top).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

When is an error not a prediction error? An electrophysiological investigation

Holroyd

Krigolson

Baker

et al. 2009

Cognitive, Affective, & Behavioral Neuroscience

159

152

View full text Add to dashboard Cite

Section: Methodssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

When is an error not a prediction error? An electrophysiological investigation

Holroyd

Krigolson

Baker

et al. 2009

Cognitive, Affective, & Behavioral Neuroscience

159

152

View full text Add to dashboard Cite

“…135,136 In contrast, when the paradigms become more difficult and include varying levels of probability and discrimination, individuals with schizophrenia show more evidence of impaired reinforcement learning. 137,138 For example, Gold and colleagues 139 found evidence for impaired learning in schizophrenia on the Frank Probabilistic Discrimination Task. A novel feature of this task is that it enables examination of reward value learning through transfer effects.…”

Section: Reward Prediction and Wanting In Schizophreniamentioning

confidence: 99%

“…60,61,66,71 Nevertheless, this literature does provide hints as to the functional integrity of ACC in schizophrenia. Several studies suggest that individuals with schizophrenia show reduced errorrelated ACC responses 137,[171][172][173][174][175][176][177] as well as reduced posterror slowing 171,172 on the Stroop task as well as other tasks. However, there is also evidence that patients with schizophrenia can show normal error correction performance even in the context of reduced ACC responses to errors 173,178 and that the relationship between the magnitude of the error related negativity and error-related behaviors is intact in schizophrenia.…”

Section: Effort Computations and Acc Function In Schizophreniamentioning

confidence: 99%

Goal Representations and Motivational Drive in Schizophrenia: The Role of Prefrontal-Striatal Interactions

Deanna

Dowd

2010

Schizophrenia Bulletin

424

325

View full text Add to dashboard Cite

The past several years have seen a resurgence of interest in understanding the psychological and neural bases of what are often referred to as ''negative symptoms'' in schizophrenia. These aspects of schizophrenia include constructs such as asociality, avolition (a reduction in the motivation to initiate or persist in goal-directed behavior), and anhedonia (a reduction in the ability to experience pleasure). We believe that these dimensions of impairment in individuals with schizophrenia reflect difficulties using internal representations of emotional experiences, previous rewards, and motivational goals to drive current and future behavior in a way that would allow them to obtain desired outcomes, a deficit that has major clinical significance in terms of functional capacity. In this article, we review the major components of the systems that link experienced and anticipated rewards with motivated behavior that could potentially be impaired in schizophrenia. We conclude that the existing evidence suggests relatively intact hedonics in schizophrenia, but impairments in some aspects of reinforcement learning, reward prediction, and prediction error processing, consistent with an impairment in ''wanting.'' As of yet, there is only indirect evidence of impairment in anterior cingulate and orbital frontal function that may support value and effort computations. However, there are intriguing hints that individuals with schizophrenia may not be able to use reward information to modulate cognitive control and dorsolateral prefrontal cortex function, suggesting a potentially important role for cortical-striatal interactions in mediating impairment in motivated and goal-directed behavior in schizophrenia.

show abstract

“…Electroencephalographic (EEG) and magnetoencephalographic (MEG) studies have identified evoked responses elicited by errors in motor tasks (error‐related negativity, ERN, Ne) (Falkenstein, Hohnsbein, & Hoormann, 1995; Holroyd & Coles, 2002; Keil, Weisz, Paul‐Jordanov, & Wienbruch, 2010) as well as by external feedback (Feedback‐Related Negativity, FRN) (Doñamayor, Marco‐Pallarés, Heldmann, Schoenfeld, & Münte, 2011; Doñamayor, Schoenfeld, & Münte, 2012b; Gehring & Willoughby, 2002; Miltner, Braun, & Coles, 1997). These neural signals appear consistently across different tasks (Meyer, Riesel, & Hajcak Proudfit, 2013; Olvet & Hajcak, 2009), are indicative of post‐error behavioral adjustments (Holroyd & Coles, 2002; Nieuwenhuis et al, 2002), and are known to be altered in a number of neuropsychiatric conditions (Gründler, Cavanagh, Figueroa, Frank, & Allen, 2009; Gu, Huang, & Luo, 2010; Morris, Heerey, Gold, & Holroyd, 2008; Morris, Holroyd, Mann‐Wrobel, & Gold, 2011; Moser, Moran, Schroder, Donnellan, & Yeung, 2013; Proudfit, 2015; Weinberg, Klein, & Hajcak, 2012). …”

Section: Introductionmentioning

confidence: 99%

Evidence for a general performance‐monitoring system in the human brain

Zubarev

Parkkonen

2018

Human Brain Mapping

View full text Add to dashboard Cite

Adaptive behavior relies on the ability of the brain to form predictions and monitor action outcomes. In the human brain, the same system is thought to monitor action outcomes regardless of whether the information originates from internal (e.g., proprioceptive) and external (e.g., visual) sensory channels. Neural signatures of processing motor errors and action outcomes communicated by external feedback have been studied extensively; however, the existence of such a general action‐monitoring system has not been tested directly. Here, we use concurrent EEG‐MEG measurements and a probabilistic learning task to demonstrate that event‐related responses measured by electroencephalography and magnetoencephalography display spatiotemporal patterns that allow an effective transfer of a multivariate statistical model discriminating the outcomes across the following conditions: (a) erroneous versus correct motor output, (b) negative versus positive feedback, (c) high‐ versus low‐surprise negative feedback, and (d) erroneous versus correct brain–computer‐interface output. We further show that these patterns originate from highly‐overlapping neural sources in the medial frontal and the medial parietal cortices. We conclude that information about action outcomes arriving from internal or external sensory channels converges to the same neural system in the human brain, that matches this information to the internal predictions.

show abstract

Learning-related changes in brain activity following errors and performance feedback in schizophrenia

Cited by 108 publications

References 32 publications

When is an error not a prediction error? An electrophysiological investigation

When is an error not a prediction error? An electrophysiological investigation

Goal Representations and Motivational Drive in Schizophrenia: The Role of Prefrontal-Striatal Interactions

Evidence for a general performance‐monitoring system in the human brain

Contact Info

Product

Resources

About