Learning Problems in Neurofibromatosis Patients

Stine, Susan B.; Adams, Wayne

doi:10.1097/00003086-198908000-00008

Cited by 39 publications

(37 citation statements)

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“…Other studies have reported mental retardation frequencies ranging from 3 to 14% (12,15,(26)(27)(28)(29)(30)(31)(32)(33). Learning difficulties were also reported in 38 of 50 (76%) patients in our study, a value higher than the percentage of 30-62% reported by others (13,14,16,(22)(23)(24)(26)(27)(28)(29)(30)(31)(33)(34)(35). Three children in the preschool age and two illiterate patients were excluded from the analyses because of learning difficulties.…”

Section: Discussioncontrasting

confidence: 66%

High frequencies of plexiform neurofibromas, mental retardation, learning difficulties, and scoliosis in Brazilian patients with neurofibromatosis type 1

Trovó-Marqui

Goloni-Bertollo

Valerio

et al. 2005

Braz J Med Biol Res

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Section: Discussioncontrasting

confidence: 66%

High frequencies of plexiform neurofibromas, mental retardation, learning difficulties, and scoliosis in Brazilian patients with neurofibromatosis type 1

Trovó-Marqui

Goloni-Bertollo

Valerio

et al. 2005

Braz J Med Biol Res

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“…No excess of mental retardation, attention deficit hyperactivity disorder, or specific learning disorders was found. Other studies document nonverbal LDs most consistently [Bawden et al, 1994;Eliason, 1988;Varnhagen et al, 1988;Stine and Adams, 1989;Wadsby et al, 1989;Moore et al, 19941. Although no personality differences were identified, the NF-1 children did elicit higher scores for aggressivehyperactive behavior [Varnhagen et al, 19881.…”

Section: Introduction Learning Disorders In Children Withmentioning

confidence: 96%

Neurobehavioral profiles of children with neurofibromatosis 1 referred for learning disabilities are sex-specific

et al. 1996

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“…The protein produced by the NF1 gene has been implicated in learning and memory [Brambilla et al, 1997] and may be the mechanism for learning deficits in NF1 [Costa et al, 2002]. Stine and Adams [1989] report that LD occurs more frequently in children with NF1 than in their siblings.…”

Section: Introductionmentioning

confidence: 99%

Studies of age‐correlated features of cognitive‐behavioral development in children and adolescents with genetic disorders

Fisch

Carpenter²,

Howard‐Peebles

et al. 2007

American J of Med Genetics Pt A

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Studies of age-related features of cognitive-behavioral deficits produced by genetic mutations permit us to draw inferences about how brain development may be related cognitive ability as the child ages. Except for Down syndrome (DS) and the fragile X mutation (FRAXA), little is known about the longitudinal changes in cognitive-behavioral development in individuals with genetic abnormalities producing learning disabilities (LD) or mental retardation (MR). The purpose of this prospective study was to compare and contrast age related to cognitive abilities, adaptive and maladaptive behaviors in children and adolescents in the same age range, diagnosed with one of three genetic disorders: the FRAXA mutation, Neurofibromatosis type 1 (NF1) or Williams-Beuren syndrome (WBS). We also sought to examine whether cognitive-behavioral abilities associated with these three genetic disorders were related systematically to age. We examined 108 children, ages 4-15 years, with FRAXA, WBS, or NF1. Results show that there is a significant negative correlation between age and IQ, and between age and adaptive behavior (DQ) scores, in children with FRAXA and WBS, but not in children with NF1. All three groups of children have unusually high proportions of maladaptive behavior, ranging from 1/6 children with NF1 to 2/3 children with FRAXA. Cognitive and adaptive behavior profiles of children with FRAXA and WBS were also surprisingly similar. Our findings suggest the need for examining longitudinal developmental cognitive-behavioral changes in children and adolescents with all genetic disorders that produce LD or MR.

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Learning Problems in Neurofibromatosis Patients

Cited by 39 publications

References 0 publications

High frequencies of plexiform neurofibromas, mental retardation, learning difficulties, and scoliosis in Brazilian patients with neurofibromatosis type 1

High frequencies of plexiform neurofibromas, mental retardation, learning difficulties, and scoliosis in Brazilian patients with neurofibromatosis type 1

Neurobehavioral profiles of children with neurofibromatosis 1 referred for learning disabilities are sex-specific

Studies of age‐correlated features of cognitive‐behavioral development in children and adolescents with genetic disorders

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