Learning, Life, and Lactation: Knowledge of Breastfeeding's Impact on Breast Cancer Risk Reduction and Its Influence on Breastfeeding Practices

Ganju, Akaansha; Suresh, Anupama; Palettas, Marilly; Burke, Diana; Miles, Laura; Lehman, Kelly; Rudesill, R; Lustberg, Maryam B.; Bose‐Brill, Seuli; Ramaswamy, Bhuvaneswari

doi:10.1089/bfm.2018.0170

Cited by 11 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Women who report a cumulative BF history of 12 months or more decrease their risk for breast and ovarian cancers, diabetes, hypertension, and return to prepregnancy body shape. 3,5,6 BF supports maternal well-being during the fourth trimester of pregnancy after birth by decreasing the risk of depression, anxiety, and stress symptoms, and it increases maternal self-efficacy. 7 BF also provides lifelong infant health benefits; the longer infants exclusively breastfeed, the greater benefit in reducing infantile and respiratory diseases (COVID- 19), sudden infant death syndrome, and chronic diseases related to obesity.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Although 42% of infants in the world meet the public health goal, only 25.6% of infants in the United States meet this target of being exclusively breast fed for the first 6 months of life. 1,2 Even more concerning is that African American (AA) women in the United States, 3 in particular, have the lowest BF initiation and continuation rates, with only 17.2% of infants exclusively breastfed at 6 months. 4 The preventative health benefit of BF increases with longer BF duration.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Black/African American Breastfeeding Experience: Cultural, Sociological, and Health Dimensions Through an Equity Lens

Gyamfi

O’Neill

Henderson

et al. 2021

Breastfeeding Medicine

View full text Add to dashboard Cite

Background: Disparities in breastfeeding (BF) continue to be a public health challenge, as currently only 42% of infants in the world and 25.6% of infants in the United States are exclusively breastfed for the first 6 months of life. In 2019, the infants least likely to be exclusively breastfed at 6 months are African Americans (AA) (17.2%). Materials and Methods: A scoping review of the literature was undertaken by using Arksey and O'Malley's sixstage framework to determine key themes of AA women's experience BF through an equity lens. Electronic databases of CINAHL and PubMed were searched for peer-reviewed, full-text articles written in the English language within the past 5 years by using the terms BF, AA, Black, sociological, cultural, equity, health, attitude, exposure, initiation, continuation, barriers, and facilitators. Results: Initially, 497 articles were identified, and 26 peer-reviewed articles met the eligibility criteria. Through an equity lens, three main themes emerged, which summarized AA women's BF experience: cultural (family, peers and community support; misconceptions; personal factors), sociological (prejudices, racism, home environment; financial status; sexuality issues; BF role models; employment policies), and health dimensions (family involvement; timely and honest information from staff; baby-friendly hospital initiatives; postnatal follow-up; special supplemental nutrition program for women, infants, and children). Conclusion: For AA women, exclusively BF is beset with diverse cultural, health, and sociological challenges. Multifaceted approaches are needed for successful resolution of BF challenges to bridge the racial gap in BF in the United States. Future studies may explore interventions targeted to modifiable barriers to improve BF outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Black/African American Breastfeeding Experience: Cultural, Sociological, and Health Dimensions Through an Equity Lens

Gyamfi

O’Neill

Henderson

et al. 2021

Breastfeeding Medicine

View full text Add to dashboard Cite

show abstract

“…Even in the case of infectious diseases, there is never an absolute contraindication to breastfeeding [8,9]. Furthermore, breastfeeding has important benefits for maternal health, such as reducing the risk for some cancers (breast cancer, ovarian cancer, and endometrial cancer) [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Uptake of Breastfeeding: The Role of Early Promotion in the Maternity Hospital

Ragusa¹,

Marranzano

Rosa

et al. 2021

IJERPH

View full text Add to dashboard Cite

Background: This study aimed to explore the prevalence of breastfeeding at birth points in Sicily and the relevance of the factors influencing the adoption of exclusive breastfeeding during hospitalization linked to childbirth. Methods: A survey was conducted to monitor the prevalence of breastfeeding in seven out of nine facilities providing maternity services in the province of Catania (Sicily, Southern Italy) in the years 2016–2018. An online questionnaire was administered using an electronic tablet by the midwife to the mother after discharge. Results: Women who had a higher educational qualification breastfed in a greater proportion (59.6%; odds ratio OR 0.60 for abandoning breastfeeding). Having had a caesarean section moderately impaired breastfeeding uptake, with an almost double chance of declining exclusive breastfeeding (OR = 1.74). Starting breastfeeding within 1 h from delivery showed a significant facilitating effect (OR = 0.58). Rooming-in had a strong facilitating effect on exclusive breastfeeding. A breastfeeding advocacy program was shown to protect from abandoning breastfeeding. Conclusions: It is important to offer in all hospitals the possibility and support for breastfeeding in the first moments after childbirth to increase the number of those who will then continue with exclusive breastfeeding.

show abstract

“…In fact, it is estimated that breastfeeding prevents 20,000 breast cancer deaths annually based on the current breastfeeding rates [10]. Yet, a study conducted by our group showed that only 16% of mothers received the information regarding this personal health benefit from breastfeeding from health care professionals [11]. Epidemiological data also show that African-American women have one of the lowest breastfeeding rates in the USA (33% compared to 63% for non-Hispanic Caucasian women) and have a disproportionate burden of developing TNBC, in particular basal-like breast cancer (BLBC) [12].…”

Section: Introductionmentioning

confidence: 99%

Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background A large collaborative analysis of data from 47 epidemiological studies concluded that longer duration of breastfeeding reduces the risk of developing breast cancer. Despite the strong epidemiological evidence, the molecular mechanisms linking prolonged breastfeeding to decreased risk of breast cancer remain poorly understood. Methods We modeled two types of breastfeeding behaviors in wild type FVB/N mice: (1) normal or gradual involution of breast tissue following prolonged breastfeeding and (2) forced or abrupt involution following short-term breastfeeding. To accomplish this, pups were gradually weaned between 28 and 31 days (gradual involution) or abruptly at 7 days postpartum (abrupt involution). Mammary glands were examined for histological changes, proliferation, and inflammatory markers by immunohistochemistry. Fluorescence-activated cell sorting was used to quantify mammary epithelial subpopulations. Gene set enrichment analysis was used to analyze gene expression data from mouse mammary luminal progenitor cells. Similar analysis was done using gene expression data generated from human breast samples obtained from parous women enrolled on a tissue collection study, OSU-2011C0094, and were undergoing reduction mammoplasty without history of breast cancer. Results Mammary glands from mice that underwent abrupt involution exhibited denser stroma, altered collagen composition, higher inflammation and proliferation, increased estrogen receptor α and progesterone receptor expression compared to those that underwent gradual involution. Importantly, when aged to 4 months postpartum, mice that were in the abrupt involution cohort developed ductal hyperplasia and squamous metaplasia. Abrupt involution also resulted in a significant expansion of the luminal progenitor cell compartment associated with enrichment of Notch and estrogen signaling pathway genes. Breast tissues obtained from healthy women who breastfed for < 6 months vs ≥ 6 months showed significant enrichment of Notch signaling pathway genes, along with a trend for enrichment for luminal progenitor gene signature similar to what is observed in BRCA1 mutation carriers and basal-like breast tumors. Conclusions We report here for the first time that forced or abrupt involution of the mammary glands following pregnancy and lack of breastfeeding results in expansion of luminal progenitor cells, higher inflammation, proliferation, and ductal hyperplasia, a known risk factor for developing breast cancer. Electronic supplementary material The online version of this article (10.1186/s13058-019-1163-7) contains supplementary material, which is available to authorized users.

show abstract

Learning, Life, and Lactation: Knowledge of Breastfeeding's Impact on Breast Cancer Risk Reduction and Its Influence on Breastfeeding Practices

Cited by 11 publications

References 22 publications

Black/African American Breastfeeding Experience: Cultural, Sociological, and Health Dimensions Through an Equity Lens

Black/African American Breastfeeding Experience: Cultural, Sociological, and Health Dimensions Through an Equity Lens

Factors Influencing Uptake of Breastfeeding: The Role of Early Promotion in the Maternity Hospital

Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

Contact Info

Product

Resources

About