Learning Is Harder with PKR

Abstract

A kinase involved in detecting viral RNA also enhances inhibitory neurotransmission in the brain.

Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma

“…Subsequent phosphorylation on IRAK1 by upstream signals or through autophosphorylation is the key post-translational modification and hallmark of its activation, which allows IRAK1 to bind to TRAF6 resulting in release of the IRAK1 homodimer from MYD88 and downstream NF-κB activation. 4 The participation of IRAK1 in signaling networks of the innate immune response makes it a critical regulator of inflammation, 5 antiviral response, 6 and subsequent activation of the adaptive immune response. 7 Consequently, an extensive investigation into physiological and pathological functions of IRAK1 in regulating these processes has been performed.…”