Learning from Our Mistakes: We Have a Scientific and Fiscal Obligation to Publish Failed Results

Abstract

<p>By only publishing the positive and successful results of our research, we as a field are limiting scientific advances and exercising poor stewardship of financial resources. By moving toward norms that include disseminating failed, unexpected, and tangential results, we have the opportunity to not only increase the efficiency of science, but also advance new discoveries. Of the broad scientific disciplines, chemistry in particular is poised to take advantage of already-existing, relatively low-barrier approaches to change the scientific publishing culture.</p>

Hydrolysis-Based Small-Molecule Hydrogen Selenide (H2Se) Donors for Intracellular H2Se Delivery

“…On the basis of these rate differences, we propose that the cyclic-PSe compounds react directly with NBD-Cl to form an intermediate that facilitates the subsequent liberation of selenide and NBD-SeH formation. Although the NBD-Cl trapping system confirms that these donors are a source of labile reduced Se, we caution other researchers that NBD-Cl trapping experiments should be complemented with other measurements for RSeS-releasing compounds to not inadvertently interpret direct donor alkylation as alkylation of released H 2 Se in solution …”