Learning Disabilities and Attentional Problems in Boys With the Fragile X Syndrome

What is associated with the fragile X syndrome?

“…Coolidge et al [19861 examined a large sample of MR adults and found their highest subtest scores were in Picture Completion and Object Assembly while their lowest scores were in Digit Span and Arithmetic. These findings are consistent with the subscale scores generated by MR fra(X) males [Hagerman et al, 1985;Kemper et al, 19881.…”

Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression

“…Priming of mGluR-LTD by recent salient experience may contribute to the plasticity of active neural networks that encode that experience. Abnormal encoding and habituation of novel experiences occurs in Fragile X syndrome (Hagerman et al, 1985; Restivo et al, 2005), a cognitive disorder associated with altered mGluR-LTD (Huber et al, 2002). Understanding the contribution of mGluR-LTD to normal cognition will help understand how altered mGluR-LTD mechanisms lead to cognitive disorders (Auerbach et al, 2011; Bozdagi et al, 2012; Huber et al, 2002; Lee et al, 2005; Li et al, 2009).…”

Effect of Recurrent Otitis Media on Language Profile in Children with Fragile X Syndrome

“…7 Children with FXS may be at increased risk for chronic middle ear infections (otitis media). 8 Hagerman et al 6 have noticed that recurrent otitis media is a frequent finding in the medical history of boys with FXS. Nielsen 16 has also noted frequent otitis media in the case history of males with FXS.…”