Learning Disabilities and Attentional Problems in Boys With the Fragile X Syndrome

Hagerman, Randi J.; Kemper, Melinda B.; Hudson, Michael

doi:10.1001/archpedi.1985.02140090036021

Cited by 40 publications

(45 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some of these findings may be much more subtle or absent in prepubertal boys [Largo and Schinzel, 1985;Hagerman, 19871, and for this reason, K-ABC scores may be particularly helpful. Behavioral characteristics include attentional problems, impulsivity, hyperactivity, and autistic-like behaviors, such as poor eye contact or hand-flapping [Levitas et al, 1983a, b;Fryns et al, 1984;Kerbeshian et al, 1984;Hagerman et al, 1985;Largo and Schinzel, 1985;Varley et al, 1985;Hagerman et al, 1986;Hagerman, 19871. Family histories often document retarded males and learning-disabled or retarded females.…”

Section: Discussionmentioning

confidence: 99%

“…The recognition of a specific pattern of cognitive strengths and weaknesses is important for identifying which hyperactive children may need chromosome testing. Hagerman et al [1985] reported on four fragile X boys with marked difficulties with arithmetic and mild problems in both receptive and expressive language skills. Early reading skills and vocabulary were areas of relative strength.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive profiles of boys with the fragile X syndrome

1988

View full text Add to dashboard Cite

Testing 20 boys with the fragile X (or Martin-Bell) syndrome with the Kaufman Assessment Battery for Children (K-ABC) showed a consistent pattern of strengths and weaknesses that may be useful in predicting a fragile X positive result from cytogenetic testing. This K-ABC pattern included 1) Sequential Scale score less than the Simultaneous Scale score; 2) Mental Processing Composite less than the Achievement Scale score; 3) Spatial Memory subtest score less than the Matrix Analogies subtest score; and 4) Arithmetic subtest score less than the mean of the Achievement subtest scores. A comparison group of 20 boys did not demonstrate such a pattern. Testing with the K-ABC should be considered for boys who present as learning disabled, hyperactive with attentional problems, or mildly retarded. Boys with three or four of the four features of the K-ABC fragile X pattern should be considered for medical evaluation and cytogenetic testing.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognitive profiles of boys with the fragile X syndrome

1988

View full text Add to dashboard Cite

show abstract

“…Approximately 1 in 260 females carry the potentially unstable mutation and are at risk for having affected children [Rousseau et al, 1995]. Clinically, fragile X syndrome is characterized by a spectrum of cognitive and behavioral disabilities [Hagerman et al, 1985;Lachiewicz et al, 1994]. A systematic survey of parents of at-risk children has not been previously undertaken.…”

Section: Introductionmentioning

confidence: 99%

Parental attitudes regarding carrier testing in children at risk for fragile X syndrome

et al. 1999

View full text Add to dashboard Cite

Sixty-five parents of individuals affected by fragile X syndrome who attended the National Fragile X Conference in Portland, Oregon (1996), were asked to complete a survey assessing parental level of concern about carrier testing in children at risk for fragile X syndrome. All subjects completed a 15-item paper and pencil Likert response scale measure that was developed specifically for this study. The items included parental rights and duties, psychological adjustment, adaptation, discrimination, harm, childbearing, and interpersonal relationships. The major concern of the parents was that their children have knowledge of their carrier status prior to becoming sexually active and that their children be able to marry informed of their genetic risk. Mothers were significantly more concerned than fathers about raising their children with the knowledge of their carrier status. A sense of parental right to make the decision regarding carrier testing for children was associated with concerns about (1) behavioral or educational problems, (2) knowledge of carrier status prior to sexual activity or marriage, and (3) adjustment of the children to knowledge of their carrier status. As the sample was drawn from a unique population of parents, the results of this survey should be interpreted with caution. The findings of this study suggest a model of parents providing anticipatory guidance for their children to help them adjust to carrier information and for their children to have this knowledge prior to the possibility of reproduction.

show abstract

“…There were numerous case reports and uncontrolled cohort studies looking at ADHD and specific populations of children with cytogenetic abnormalities [7][8][9][10][11][12][13][14][15] (see table 2). …”

Section: Commentarymentioning

confidence: 99%