Learning curve for the detection of axillary sentinel lymph node in breast cancer

Classe, Jean‐Marc; Curtet, C.; Campion, Loı̈c; Rousseau, Caroline; Fiche, Maryse; Sagan, Christine; Resche, I.; Pioud, R.; Andrieux, N.; Dravet, F.

doi:10.1016/s0748-7983(03)00052-0

Cited by 39 publications

(20 citation statements)

References 39 publications

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“…Rapid identification of the SLN in patients with NSCLC should improve as thoracic surgeons become more familiar with the technique, similar to what has occurred in other tumor types. 42,43 The current study data indicate that RT-PCR for CK7 is a highly sensitive marker for NSCLC. The use of a single tube for the entire nested RT-PCR assay decreases the risk of false-positive results that arise from contamination.…”

Section: Discussionmentioning

confidence: 61%

Sentinel lymph node mapping and molecular staging in nonsmall cell lung carcinoma

Pulte

Crawford

et al. 2005

Cancer

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An overview on all hydrogen‐bonded helix types, which can be expected in the novel class of β/δ‐hybrid peptides, is provided on the basis of ab initio molecular orbital theory. The results show a considerable potential of different folding patterns, which makes this novel class of peptide foldamers interesting for peptide and protein design. Thus, this study may stimulate the synthesis of such hybrid peptides. The large number of helix types found for β/δ‐hybrid peptides together with the many helices experimentally found and theoretically predicted in the other classes of peptide and hybrid peptide foldamers provide a good basis to establish general correspondence rules for their mutual exchange in peptide sequences. This is done by introduction of the concept of pattern and shape correspondence. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 279–291, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

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Section: Discussionmentioning

confidence: 61%

Sentinel lymph node mapping and molecular staging in nonsmall cell lung carcinoma

Pulte

Crawford

et al. 2005

Cancer

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“…In this analysis, patients undergoing SNB have a 22% higher odds ratio of having a positive node, a finding that is likely to be due to the more intensive pathologic examination using multiple sections and immunohistochemistry (IHC) which is employed to evaluate the sentinel node and which makes detection of malignant cells more likely [17]. Whilst it is clear that there is a false negative rate associated with identification of incorrect nodes as the sentinel node or failure to identify all of the sentinel nodes, this source of false negative results decreases with increasing experience of the surgeon [18]. In contrast, the false negative rate seen with axillary dissection is due to the inability of the pathologist to perform serial sections and IHC on the 20-30 lymph nodes found in an axillary dissection specimen and is not anticipated to decrease, leading us to believe that the staging advantage for SNB observed in this study is likely to increase in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Another potential limitation is that the results of recently launched randomized studies were not available to include in the meta-analysis, and data from some published studies could not be extracted. It is also possible that despite some initial training, surgeons may have been developing skills in SNB during the studies included, so the morbidity may reflect still some part of the ''learning curve'' in this procedure [18].…”

Section: Discussionmentioning

confidence: 99%

Outcome of axillary staging in early breast cancer: a meta-analysis

Kell

Burke

Barry

et al. 2010

Breast Cancer Res Treat

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Axillary lymph node dissection (ALND) is associated with significant morbidity, whilst sentinel node biopsy (SNB) has the potential to minimize complications in the management of breast cancer. The aim of this study was to systematically appraise the outcome of SNB when compared to ALND. A comprehensive search for published trials examining outcomes after SNB for breast cancer was performed using medline and cross-referencing available data. Each study was reviewed and data extracted. Primary outcomes were nodal positivity and surgery-related morbidity. A total of 9,608 patients were identified from trials comparing ALND and SNB. The overall rate of axillary lymph node positivity for those with no clinically palpable nodes was 28.8% for ALND and 27.6% for SNB (OR = 1.00, 95% CI = 0.86-1.17, P = 0.956), though there was a trend for superior detection of metastatic disease with SNB when this was compared with ALND alone (OR = 1.22, 95% CI = 0.95-1.57, P = 0.122). Patients who undergo SNB are significantly less likely to suffer post-operative morbidity relative to ALND: risk of infection (OR = 0.58, 95% CI = 0.42-0.80, P = 0.0011), seroma (OR = 0.40, 95% CI = 0.31-0.51, P = 0.0071), arm swelling (OR = 0.30, 95% CI = 0.14-0.66, P = 0.0028) and numbness (OR = 0.25, 95% CI = 0.1-0.59, P = 0.0018).SNB is at least equivalent to ALND in detecting metastatic disease in the axilla. SNB is the optimum approach in terms of morbidity for the assessment of axillary metastasis in clinically node negative breast cancer.

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“…Dans cette étude, une seule ponction était nécessaire dans le GS, contre une à sept ponctions dans le groupe CA. Classe et al [27] rapportent un taux de sérome de 11 %, après prélèvement du GS. Purushotham et al [28] confirment ces mêmes taux (21 % versus 14 %) dans une étude randomisée contrôlée portant sur 298 patientes.…”

Section: Prévention Peropératoire De La Formation Des Séromesunclassified