Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population

Abstract

Lean-NAFLD has unique results in demographic, biochemical and blood examinations, and adds significant risk for diabetes, hypertension and MetS in lean individuals.

Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

“…There are some studies showing that even non-overweight or non-obese persons with NAFLD are at risk for development of T2D, but in none of these studies were all metabolic components adjusted to the finding [38][39][40][41]. Additionally, NAFLD has been linked to the components of metabolic disorders in general, mostly by cross-sectional studies [42,43] that do not provide any evidence of the causality of the studied entities.…”

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

“…2; see Supple mentary information S1,S2 (tables)) 45,49,50,56,[67][68][69][70][71][72][73][74][75][76][77][78] . This manifestation of NAFLD deserves clinical attention as many physicians have a perception that lean NAFLD is more benign in nature than NAFLD in individuals who are obese.…”

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

“…For instance, lean (defined by BMI) Asian Indians show lower insulin sensitivity than other races of Asian descent but also higher body fat percentage and waist circumference [28]. Similarly, lean Chinese participants have NAFLD which also correlates with higher waist circumference and poorer metabolic outcomes such as blood glucose, blood pressure, and insulin levels [29]. One should keep in mind that for a given BMI, Chinese subjects tend to accumulate fat intra-abdominally and thus even lean subjects may have ectopic fat deposition and intra-abdominal obesity.…”