Design processes generate inputs to plan and control the development of project construction processes. There is a growing interest in implementing design techniques involving various options to reach a systemic overview and select the best proposal. One such technique is Set-Based Design (SBD) which identifies and explores multiple design options simultaneously. Although several studies have been carried out focused on the SBD implementation in construction projects, there need to be more studies that synthesize the main findings to facilitate a proper implementation according to the different contexts. Considering this gap, this paper focuses on presenting a synthesis of SBD's benefits, difficulties, and trends in construction projects. The research method corresponds to a systematic literature review of a sample of 281 documents initially drawn from Scopus database and finally, with 32 documents screened, this study undertook the following stages. The research method has five stages: 1) scope definition; 2) searching of relevant documents; 3) document selection; 4) evidence collection, analysis, and synthesis; and 5) results report. The findings show a trend towards adopting the SBD technique for the design of structural elements of buildings and bridges. The three most frequently reported benefits of SBD adoption are: 1) transparent decision-making processes, 2) better collaboration in decision-making, and 3) better communication among designers. The three most frequently reported difficulties 1) inadequate organizational structure for the adoption of SBD, 2) lack of staff experience, 3) resistance to change in organizations.