Lean BMIs as markers of malnutrition in chronic obstructive pulmonary disease patients

Salama, Suzan; Mohamed-Hussein, Aliae; Khalil, Medhat A.; Eid, Samir

doi:10.4103/1687-8426.176663

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with these findings, the present study also showed that FFMI was decreased in patients with COPD compared with the control group. The mechanisms of muscle mass reduction and muscle dysfunction in patients with COPD are not fully understood, and are mainly related to inflammatory activity, oxidative and nitrative stress, hypoxia and hypercapnia, blockade of neuromuscular transmission by smoking, and glucocorticoid use ( 30 ). In addition, it has been found that changes in BMI and FFMI are closely related to the severity of airflow limitation in patients with COPD: the BMI of patients with an extremely severe degree of airflow limitation is significantly lower than that of patients with a moderate/severe degree, which may be due to the fact that patients with higher BMI have better nutritional status and higher muscle mass, and can do more exercise to further increase their respiratory muscle content, thus improving their lung function ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Jin,

Yang,

Chen

et al. 2024

Front. Med.

View full text Add to dashboard Cite

BackgroundBody composition changes are important extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) patients. This study aimed to investigate the characteristics of body composition in patients with COPD, and its correlation with disease severity.MethodsA total of 105 COPD patients admitted to Zhongshan Hospital affiliated to Dalian University, from May 1, 2021 to January 31, 2023, were included as the COPD group, and 105 subjects without COPD were enrolled as the control group during the same period. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) comprehensive assessment indicators, COPD patients were divided into groups: the degree of pulmonary function airflow limitation was grouped according to FEV1%pred; clinical symptoms were grouped according to mMRC scores and CAT scores; the risk of acute exacerbation was divided into low risk and high risk groups. Body composition was measured by bioelectrical impedance analysis (BIA).Results(1) Concerning body composition, the body mass index (BMI), fat-free mass index (FFMI), and angle of phase (PhA) of COPD patients were lower than those of the control group. Extracellular water-to-total body water ratio (ECW/TBW) and extra-to-intracellular water ratio (ECW/ICW) were higher than those of the control group, and the difference was statistically significant (p < 0.05). (2) There were differences in body composition among COPD patients with different severity of disease: FFMI and PhA in the mild/moderate airflow limitation group were higher than those in the severe/very severe airflow limitation group. According to mMRC scores classification, the FFMI and PhA of the less symptomatic group were higher than those of the more symptomatic group, and ECW/TBW and ECW/ICW were lower than those of the more symptomatic group. According to CAT scores classification, FFMI and PhA in the mild/moderate disease group were higher than those in the severe/very severe disease group. The FFMI of the low-risk group was higher than that of the high-risk group, and ECW/TBW was lower than that of the high risk group. (3) Correlation analysis between body composition and disease severity indicators showed that FFMI and PhA were negatively correlated with mMRC scores and CAT scores, and positively correlated with FEV1%pred. ECW/TBW ratio and ECW/ICW ratio were positively correlated with mMRC scores and CAT scores, and negatively correlated with FEV1%pred, and the difference was statistically significant (p < 0.05).ConclusionThere are significant differences in body composition between COPD patients and the control group, and there are significant differences in body composition between COPD patients with different severity of disease, with correlations between body composition and severity of disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Jin,

Yang,

Chen

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

Association between hand grip strength with weaning and intensive care outcomes in COPD patients: A pilot study

Mohamed-Hussein

Makhlouf

Selim

et al. 2018

Clinical Respiratory J

View full text Add to dashboard Cite

BackgroundIn COPD, weight loss and muscle wasting contribute significantly to morbidity, disability, and handicap. Dominant‐handgrip strength for evaluation of muscle strength has not been tested as a parameter to predict outcome of weaning from mechanical ventilation (MV).ObjectivesTo evaluate the association between handgrip strength and the duration and success of weaning and extubation outcome.Materials and methodsThis prospective study included 34 COPD patients requiring MV for at least 48 hours. Recovery from sedation and muscle relaxants was assessed before recruitment. Serial meseaurment of handgrip strength were assessed by trained personnel.ResultsThere was a significant negative correlation between baseline hand grip and duration of MV (P = .047, r = −.343). The mean day 5 hand grip was significantly lower in person who died compared to survivors (5.7 ± 5.5 vs 18.2 ± 14.5, P = .044). The mean day 5 hand grip was significantly lower in patients who needed reintubation compared to those in patients who did not need reintubation (2.8 ± 2 vs 17.2 ± 13.9, P = .029). There was no significant difference in the mean baseline, day 2, day 3, day 4 and day 5 hand grip in weaning success compared to those in failure (P > .05).ConclusionHandgrip strength may be good predictor for duration of MV, extubation outcome, ICU mortality and prognosis.

show abstract

Lean BMIs as markers of malnutrition in chronic obstructive pulmonary disease patients

Cited by 2 publications

References 15 publications

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Association between hand grip strength with weaning and intensive care outcomes in COPD patients: A pilot study

Contact Info

Product

Resources

About