Leaky Blood–Brain Barrier: A Double Whammy for the Brain

Wang, Yu

doi:10.1177/1535759720917920

Cited by 1 publication

(1 citation statement)

References 9 publications

(8 reference statements)

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“…[104,105] Given that the BBB is often compromised in many brain diseases [165] and that damaged vessels are particularly prevalent in cancer treatment, a better localized delivery method for the treatments of these diseases is of the utmost importance. [166,167] Such studies highlight the clinical importance of developing methods to reduce or eliminate offtarget distribution of viral vectors in gene delivery, with much research to date focused on targeting viral vectors to specific cells or tissues. [168][169][170] Transcriptional targeting (a particular segment of DNA being copied into messenger RNA (mRNA), the first step of gene expression) and transductional targeting (targeting specific surface receptors expressed on target cells) have been extensively used with some promising results.…”

Section: Toxicity and Off-target Effects By Dissemination Of Viral Vementioning

confidence: 99%

Is Viral Vector Gene Delivery More Effective Using Biomaterials?

Wang

Bruggeman

Franks

et al. 2020

Adv Healthcare Materials

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Gene delivery has been extensively investigated for introducing foreign genetic material into cells to promote expression of therapeutic proteins or to silence relevant genes. This approach can regulate genetic or epigenetic disorders, offering an attractive alternative to pharmacological therapy or invasive protein delivery options. However, the exciting potential of viral gene therapy has yet to be fully realized, with a number of clinical trials failing to deliver optimal therapeutic outcomes. Reasons for this include difficulty in achieving localized delivery, and subsequently lower efficacy at the target site, as well as poor or inconsistent transduction efficiency. Thus, ongoing efforts are focused on improving local viral delivery and enhancing its efficiency. Recently, biomaterials have been exploited as an option for more controlled, targeted and programmable gene delivery. There is a growing body of literature demonstrating the efficacy of biomaterials and their potential advantages over other delivery strategies. This review explores current limitations of gene delivery and the progress of biomaterial‐mediated gene delivery. The combination of biomaterials and gene vectors holds the potential to surmount major challenges, including the uncontrolled release of viral vectors with random delivery duration, poorly localized viral delivery with associated off‐target effects, limited viral tropism, and immune safety concerns.

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