2022
DOI: 10.21203/rs.3.rs-2309747/v1
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Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities

Abstract: Engineering functional cardiac tissues would represent a therapeutic alternative for patients with end-stage heart disease. Recapitulating the complex structural, mechanical, and electrophysiological properties of the heart is crucial to improving the utility of the engineered cardiac tissues. Here, we report a leaf-venation-directed strategy that enables the contraction and remodeling of cell-hydrogel hybrids into a highly aligned and densely packed organization in predetermined patterns. This strategy contri… Show more

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