Leaf-specific suppression of deoxyhypusine synthase in Arabidopsis thaliana enhances growth without negative pleiotropic effects

Duguay, Jeremy; Jamal, Sadaf; Liu, Zhongda; Wang, Tzann‐Wei; Thompson, John E.

doi:10.1016/j.jplph.2006.02.001

Cited by 39 publications

(32 citation statements)

References 32 publications

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“…Suppression of DHS exhibits delayed natural senescence (Duguay et al 2007;Wang et al 2003;Wang et al 2005), indicating that eIF5A is involved in programmed cell death (PCD). There are three isoforms of eIF5A in Arabidopsis thaliana (Thompson et al 2004;Wang et al 2003).…”

Section: Introductionmentioning

confidence: 99%

RceIF5A, encoding an eukaryotic translation initiation factor 5A in Rosa chinensis, can enhance thermotolerance, oxidative and osmotic stress resistance of Arabidopsis thaliana

Zhang

Jiang

et al. 2010

Plant Mol Biol

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Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein known to contain the unusual amino acid hypusine. It is a highly conserved protein found in all eukaryotic organisms. Although originally identified as a translation initiation factor, recent studies suggest that eIF5A is mainly involved in translation elongation, mRNA turnover and decay, cell proliferation, and programmed cell death. However, the precise cellular function of eIF5A remains largely unknown, especially in plants. Here, we report the identification and characterization of RceIF5A from Rosa chinensis. RceIF5A expression is up-regulated in Rosa chinensis under high temperature, and oxidative and osmotic stress conditions. We produced transgenic Arabidopsis that constitutively enhanced or suppressed expression of RceIF5A. The RceIF5A over-expression plants exhibited increased resistance to heat, and oxidative and osmotic stresses, while the suppressed expression plants (three AteIF5A isoforms in Arabidopsis were down-regulated) showed more susceptibility to these stresses. These results reveal a new physiological role for eIF5A in plants and contribute to the elucidation of the molecular mechanisms involved in the stress response pathway.

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Section: Introductionmentioning

confidence: 99%

RceIF5A, encoding an eukaryotic translation initiation factor 5A in Rosa chinensis, can enhance thermotolerance, oxidative and osmotic stress resistance of Arabidopsis thaliana

Zhang

Jiang

et al. 2010

Plant Mol Biol

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“…The sequence of plant eIF5A is highly conserved, especially in the regions bordering the site of hypusination (Thompson et al, 2004), suggesting that all of the isoforms of plant eIF5A are capable of being hypusinated. However, there appears to be only one isoform of DHS in plants (Thompson et al, 2004;Duguay et al, 2006). That this single isoform of DHS is involved in posttranslational modification of more than one isoform of eIF5A is supported by the finding that suppression of DHS has pleiotropic effects.…”

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confidence: 97%

“…Studies with transgenic plants have provided evidence for the involvement of eIF5A in programmed cell death associated not only with leaf senescence but also fruit senescence and petal senescence (Wang et al, 2001Duguay et al, 2006;Hopkins et al, 2007). In addition, a fumonisin B 1 -resistant12 (fbr12) Arabidopsis mutant was recently determined to be an AteIF5A-2 knockout (Feng et al, 2007).…”

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confidence: 99%

Eukaryotic Translation Initiation Factor 5A Is Involved in Pathogen-Induced Cell Death and Development of Disease Symptoms in Arabidopsis

et al. 2008

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“…In Arabidopsis , three isoforms (eIF5A1, eIF5A2, and eIF5A3) have been described with distinct expression patterns and apparent different functions. AteIF5A1 is localized in senescing leaf tissue suggesting that it plays a role in senescence (Duguay et al, 2007). AteIF5A2 has been shown to be involved in both pathogen-induced cell death and the development of disease symptoms (Hopkins et al, 2008).…”

Section: Pumpkin Eukaryotic Translation Initiation Factor 5amentioning

confidence: 99%

Phloem RNA-binding proteins as potential components of the long-distance RNA transport system

Pallás

Gómez

2013

Front. Plant Sci.

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RNA-binding proteins (RBPs) govern a myriad of different essential processes in eukaryotic cells. Recent evidence reveals that apart from playing critical roles in RNA metabolism and RNA transport, RBPs perform a key function in plant adaptation to various environmental conditions. Long-distance RNA transport occurs in land plants through the phloem, a conducting tissue that integrates the wide range of signaling pathways required to regulate plant development and response to stress processes. The macromolecules in the phloem pathway vary greatly and include defense proteins, transcription factors, chaperones acting in long-distance trafficking, and RNAs (mRNAs, siRNAs, and miRNAs). How these RNA molecules translocate through the phloem is not well understood, but recent evidence indicates the presence of translocatable RBPs in the phloem, which act as potential components of long-distance RNA transport system. This review updates our knowledge on the characteristics and functions of RBPs present in the phloem.

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Leaf-specific suppression of deoxyhypusine synthase in Arabidopsis thaliana enhances growth without negative pleiotropic effects

Cited by 39 publications

References 32 publications

RceIF5A, encoding an eukaryotic translation initiation factor 5A in Rosa chinensis, can enhance thermotolerance, oxidative and osmotic stress resistance of Arabidopsis thaliana

RceIF5A, encoding an eukaryotic translation initiation factor 5A in Rosa chinensis, can enhance thermotolerance, oxidative and osmotic stress resistance of Arabidopsis thaliana

Eukaryotic Translation Initiation Factor 5A Is Involved in Pathogen-Induced Cell Death and Development of Disease Symptoms in Arabidopsis

Phloem RNA-binding proteins as potential components of the long-distance RNA transport system

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