Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling

Ahl, Louise Isager; Schoeneburg, Mia Prehn; Harth, Lisa; Barnes, Christopher J.; Woetmann, Anders; Rønsted, Nina

doi:10.1016/j.phyplu.2022.100397

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…Since ancient times, traditional medicine has made extensive use of the species Aloe vera (L.) Burm.f. (Asphodelaceae) [ 6 ]. Its mucilaginous fluid is administered to wounds and cuts in rural areas of the continent to suppress infections and promote healing [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although inflammation is a normal part of healing, Aloe’s anti-inflammatory properties appear to promote tissue recovery [ 12 ]. Although Aloe leaf gel has been used for many years, little is known about the pharmacological effects of its constituent parts [ 6 ]. It has been stated that the leaf gel of many Aloe species exhibits anti-inflammatory qualities, and research suggests that this property may be specifically related to TLR4-mediated reactions.…”

Section: Introductionmentioning

confidence: 99%

“…It has also been shown that Aloe species at a gel concentration of 0.2% significantly reduces the NF-κB activity with LPS but has no discernible effect on FSL-1. Moreover, it appears that Aloe gel extracts are more effective at inhibiting LPS’s ability to activate the TLR4 pathway [ 6 ]. A recent assessment on Aloe and skin protection activities found that the constituents have not been sufficiently investigated to draw definite conclusions about their effects [ 13 ], and this warrants more investigative research studies for clarity, understanding, and validation.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Macharia,

Ngure,

Emődy

et al. 2023

Pharmaceutics

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Aloe species are widespread and diverse in African ecosystems, and this commonly correlates to their habitual use as reservoirs of herbal medicine. The side effects associated with chemotherapy and the development of antimicrobial resistance to empirically used antimicrobial drugs are substantial, paving the way for novel phytotherapeutic approaches. This comprehensive study aimed to evaluate and present Aloe secundiflora (A. secundiflora) as a compelling alternative with potential benefits in colorectal cancer (CRC) treatment. Important databases were systematically searched for relevant literature, and out of a large collection of 6421 titles and abstracts, only 68 full-text articles met the inclusion criteria. A. secundiflora possesses an abundant presence of bioactive phytoconstituents in the leaves and roots, including anthraquinones, naphthoquinones, phenols, alkaloids, saponins, tannins, and flavonoids, among others. These metabolites have proven diverse efficacy in inhibiting cancer growth. The presence of innumerable biomolecules in A. secundiflora signifies the beneficial effects of incorporating the plant as a potential anti-CRC agent. Nonetheless, we recommend further research to determine the optimal concentrations necessary to elicit beneficial effects in the management of CRC. Furthermore, they should be investigated as potential raw ingredients for making conventional medications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Macharia,

Ngure,

Emődy

et al. 2023

Pharmaceutics

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“…Since ancient times, traditional medicine has made extensive use of the species Aloe vera (L.) Burm. f. (Asphodelaceae) [96]. Its mucilaginous fluid is administered to wounds and cuts in rural areas of the country to suppress infections and promote healing [97].…”

Section: Ethnomedicinal Utility Of the Plant Genus Aloementioning

confidence: 99%

“…Although inflammation is a normal part of healing, Aloe's anti-inflammatory properties appear to promote tissue recovery [102]. Although aloe leaf gel has been used for many years, little is known about the pharmacological effects of its constituent parts [96]. It has been stated that the leaf gel of many Aloe species exhibited anti-inflammatory qualities, and research suggests that this property may be specifically related to TLR4-mediated reactions.…”

Section: Ethnomedicinal Utility Of the Plant Genus Aloementioning

confidence: 99%

Evaluation And Determination Of The Phytotherapeutic Properties Of Selected Plants And Their Bioactive Metabolites On Targeted Genes In Colorectal Cancer Management

Macharia

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This extensive research aimed to evaluate and determine the phytotherapeutic properties of selected plants and their bioactive metabolites on targeted genes in colorectal cancer (CRC) management. The plants evaluated were Withania somnifera, Warbugia ugandensis, and Aloe secundiflora, while the targeted genes were COX-2, CASP9, Bcl-xL, Bcl2 and 5-LOX in CRC cell lines (Caco-2). To establish critical gaps in this important topic, extensive and well-thought systematic reviews were conducted at the initial stage of the study. Plant extracts were obtained using serial exhaustive extraction using three different extraction solvents (Hexane, Ethyl acetate, and Methanol). Our unique study reports on these important plants as efficient natural inhibitors of CRC growth, by directly linking their phytoconstituents to; the downregulation of COX-2, 5-LOX, Bcl-xL, Bcl2, and upregulation of CASP9 genes dose-dependently. I strongly present Withania somnifera, Warbugia ugandensis, and Aloe secundiflora plant extracts as promising natural inhibitors for CRC carcinogenesis and recommend in vivo and subsequent clinical trials, with substantial clinical effects postulated. In addition, methanol and ethyl acetate can extract metabolites exhibiting higher regulatory effects on the targeted genes and are thus highly recommended for application in yielding maximum benefits. Finally, I suggest studies on the identification and characterization of the specific metabolites in these plants, that are involved in the modulatory mechanisms, resulting in the inhibition of CRC growth and possible metastases.

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The effect of Aloe vera juice and acemannan on postprandial lipemic, antioxidant, and inflammatory response in high-fat meal fed overweight/obese men: A randomized crossover-controlled study

Thilavech,

Chumroenvidhayakul,

Chusak

et al. 2024

Journal of Functional Foods

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Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling

Cited by 3 publications

References 15 publications

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Evaluation And Determination Of The Phytotherapeutic Properties Of Selected Plants And Their Bioactive Metabolites On Targeted Genes In Colorectal Cancer Management

The effect of Aloe vera juice and acemannan on postprandial lipemic, antioxidant, and inflammatory response in high-fat meal fed overweight/obese men: A randomized crossover-controlled study

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