Leaf Development

Tsukaya, Hirokazu

doi:10.1199/tab.0163

Cited by 114 publications

(57 citation statements)

References 166 publications

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“…In Arabidopsis , leaf morphogenesis is initiated at the flanks of the shoot apical meristem (SAM) where leaf primordia develop as flattened lamina with defined abaxial, adaxial and marginal cell types (Tsukaya, 2013). Lamina development requires the juxtaposition of abaxial/adaxial polarity factors, including adaxial class III HD-Zip and abaxial KANADI transcription factors.…”

Section: Resultsmentioning

confidence: 99%

Active suppression of a leaf meristem orchestrates determinate leaf growth

Alvarez

Furumizu

Efroni

et al. 2016

eLife

134

133

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Leaves are flat determinate organs derived from indeterminate shoot apical meristems. The presence of a specific leaf meristem is debated, as anatomical features typical of meristems are not present in leaves. Here we demonstrate that multiple NGATHA (NGA) and CINCINNATA-class-TCP (CIN-TCP) transcription factors act redundantly, shortly after leaf initiation, to gradually restrict the activity of a leaf meristem in Arabidopsis thaliana to marginal and basal domains, and that their absence confers persistent marginal growth to leaves, cotyledons and floral organs. Following primordia initiation, the restriction of the broadly acting leaf meristem to the margins is mediated by the juxtaposition of adaxial and abaxial domains and maintained by WOX homeobox transcription factors, whereas other marginal elaboration genes are dispensable for its maintenance. This genetic framework parallels the morphogenetic program of shoot apical meristems and may represent a relic of an ancestral shoot system from which seed plant leaves evolved.DOI: http://dx.doi.org/10.7554/eLife.15023.001

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Section: Resultsmentioning

confidence: 99%

Active suppression of a leaf meristem orchestrates determinate leaf growth

Alvarez

Furumizu

Efroni

et al. 2016

eLife

134

133

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“…It is well known that this process requires the participation of a variety of regulators, including hormones, small RNAs, and transcription factors, that function in a multilayered regulatory network to influence development (Tsukaya, 2013). The morphological abnormalities observed in clb5 occur earlier in development and are more severe than the ones observed in mutants like cla1 and pds3.…”

Section: Discussionmentioning

confidence: 99%

An Uncharacterized Apocarotenoid-Derived Signal Generated in ζ-Carotene Desaturase Mutants Regulates Leaf Development and the Expression of Chloroplast and Nuclear Genes inArabidopsis

et al. 2014

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In addition to acting as photoprotective compounds, carotenoids also serve as precursors in the biosynthesis of several phytohormones and proposed regulatory signals. Here, we report a signaling process derived from carotenoids that regulates early chloroplast and leaf development. Biosynthesis of the signal depends on z-carotene desaturase activity encoded by the z-CAROTENE DESATURASE (ZDS)/CHLOROPLAST BIOGENESIS5 (CLB5) gene in Arabidopsis thaliana. Unlike other carotenoiddeficient plants, zds/clb5 mutant alleles display profound alterations in leaf morphology and cellular differentiation as well as altered expression of many plastid-and nucleus-encoded genes. The leaf developmental phenotypes and gene expression alterations of zds/clb5/spc1/pde181 plants are rescued by inhibitors or mutations of phytoene desaturase, demonstrating that phytofluene and/or z-carotene are substrates for an unidentified signaling molecule. Our work further demonstrates that this signal is an apocarotenoid whose synthesis requires the activity of the carotenoid cleavage dioxygenase CCD4.

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“…The identity of cells in the abaxial domain depends on the expression of KANADI [ KAN ; which encodes a Golden2/ Arabidopsis response-regulator/P starvation/acclimatization response (Psr1; GARP) transcription factor; Eshed et al, 2001; Kerstetter et al, 2001] and the YABBY gene family (Siegfried et al, 1999; Eshed et al, 2004). These two classes of genes produce signals that suppress each other’s expression: the expression of PHB/PHV/REV genes in cells located at the abaxial side is inhibited de by KAN and inversely KAN expression in abaxially located cells in inhibited by the activity of PHB/PHV/REV genes, providing a feedback communication between the two sides (Tsukaya, 2013b; Figure 4 ).…”

Section: Processes That Control Leaf Growthmentioning

confidence: 99%

Leaf development: a cellular perspective

2014

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Through its photosynthetic capacity the leaf provides the basis for growth of the whole plant. In order to improve crops for higher productivity and resistance for future climate scenarios, it is important to obtain a mechanistic understanding of leaf growth and development and the effect of genetic and environmental factors on the process. Cells are both the basic building blocks of the leaf and the regulatory units that integrate genetic and environmental information into the developmental program. Therefore, to fundamentally understand leaf development, one needs to be able to reconstruct the developmental pathway of individual cells (and their progeny) from the stem cell niche to their final position in the mature leaf. To build the basis for such understanding, we review current knowledge on the spatial and temporal regulation mechanisms operating on cells, contributing to the formation of a leaf. We focus on the molecular networks that control exit from stem cell fate, leaf initiation, polarity, cytoplasmic growth, cell division, endoreduplication, transition between division and expansion, expansion and differentiation and their regulation by intercellular signaling molecules, including plant hormones, sugars, peptides, proteins, and microRNAs. We discuss to what extent the knowledge available in the literature is suitable to be applied in systems biology approaches to model the process of leaf growth, in order to better understand and predict leaf growth starting with the model species Arabidopsis thaliana.

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Leaf Development

Cited by 114 publications

References 166 publications

Active suppression of a leaf meristem orchestrates determinate leaf growth

Active suppression of a leaf meristem orchestrates determinate leaf growth

An Uncharacterized Apocarotenoid-Derived Signal Generated in ζ-Carotene Desaturase Mutants Regulates Leaf Development and the Expression of Chloroplast and Nuclear Genes inArabidopsis

Leaf development: a cellular perspective

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