Leaf alkaloids of Rauwolfia vomitoria

Amer, Mohammed; Court, W. E.

doi:10.1016/s0031-9422(00)83823-6

Cited by 26 publications

(14 citation statements)

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“…and R. caffra Sond. (Apocynaceae) are rich in indole alkaloids most of which have been isolated and identified [7,8]. The phytochemical analysis on R. vomitoria revealed roots to have high concentration of reserpine and ajmaline.…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of Rauvolfia vomitoria and R. caffra

Erasto¹,

Lubschagne²,

Mbwambo³

et al. 2011

Spatula DD

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AIM: This study aimed to investigate the antimycobacterial activity of total alkaloid and ethanolic aqueous extracts of Rauvolfia vomitoria and R. caffra. It further aimed to evaluate antioxidant activity and cytotoxicity effect of the extracts which would have shown high antimycobacterial efficacy. METHODS: The alkaloids from the roots of two plant species were extracted according to standard procedures. Antimycobacterial activity of the extracts was evaluated using a two fold microdilution method. The antioxidant activity of the alkaloids and ethanolic extracts was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing capacity assays. The potential cytotoxicity of the extracts was evaluated using brine shrimp toxicity assay. Comparison of alkaloidal composition of the two alkaloidal extracts was done using HPLC analysis. RESULTS: The study revealed that, alkaloid extracts from the roots of Rauvolfia species had higher antimycobacterial activity against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP). The minimum inhibition concentration (MIC) values of alkaloid extracts ranged between 0.078 to 1.25 mg/ml, while the ethanolic extracts were generally moderately active against test organism. The alkaloids and ethanolic aqueous extracts of R. vomitoria exhibited high antioxidant activity. In the cytotoxicity assay, extracts did not exhibit any toxicity against brine shrimps. CONCLUSION: The alkaloids from the roots of R. vomitoria have high antimycobacterial and antioxidant activity. The alkaloids ability to inhibit the growth of two Mycobacterium strains may be associated to its antioxidant activity. The cytotoxicity of the most active extract is negligible when compared to the standard anticancer drug, this may explain why R. vomitoria is highly used in the treatment of various infectious and physiological ailments. ÖZET AMAÇ: Çalışmada Rauvolfia vomitoria ve R. caffra alkaloid ve etanolik sıvı ekstrelerinin antimikobakteriyel etkilerinin araştırılması ve ayrıca, yüksek antimikobakteriyel etki gösterecek olan ekstrelerin antioksidan ve sitotoksik etkilerinin değerlendirilmesi amaçlandı. YÖNTEM: Alkoloidler, standart prosedürlere göre iki bitkinin köklerinden ekstrakte edildi. Ekstrelerin antimikobakteriyel etkileri, iki kat mikrodilüsyon metodu kullanılarak değerlendirildi. Alkaloidlerin ve etanol ekstrelerin antioksidan etkileri 1,1-difenil-2-pikrilhidrazil (DPPH) ve indirgeyen kapasite analizleri kullanılarak saptandı. Ekstrelerin potansiyel sitotoksisitesi, tuzlu su karidesi toksisite analizi kullanılarak değerlendirildi. İki alkoloidal ekstrenin alkoloidal bileşiminin karşılaştırılması, HPLC analizi kullanılarak yapıldı. BULGULAR: Çalışmamız, Rauvolfia türlerinin köklerinden elde edilen alkaloid ekstrelerin, Mycobacterium madagascariense (MM) and M. indicus pranii (MIP)'ye karşı yüksek antimikobakteriyel etkiye sahip olduğunu göstermiştir. Alkoloid ekstrelerin minimum inhibitör konsantrasyonları (MIC), 0.078-1.25 mg/ml arasında değişirken, etanolik ekstreler, genellikle orta derece...

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Section: Introductionmentioning

confidence: 99%

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of Rauvolfia vomitoria and R. caffra

Erasto¹,

Lubschagne²,

Mbwambo³

et al. 2011

Spatula DD

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“…A number of species of Rauwolfia are well known for their alkaloids (Court and Habib 1973, Chatterjee and Bandyopadhyay 1979, Amer and Court 1980, Akinloye and Court 1981a, 1981b, Banerjee 1983, Court 1983, Nasser and Court 1984, Shimolina et al . 1984, Kan et al 1986, Yamamoto and Yamada 1987 but mainly three species, R .…”

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confidence: 99%

Chromosome constitution and alkaloid content in Rawolfia L.(Apocynaceae).

Banerjee

Sharma

1989

CYTOLOGIA

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“…1) (Tables I and II) and by comparison with published data for similar alkaloids (Pousset et al, 1967;Ripperger, 1977;Lounasmaa and Kan, 1980;Seki et al, 1993). Alkaloids 1 -3 proved to be caboxine A, caboxine B, and isocaboxine B, and 4 and 5 were found to be carapanaubine and isocarapanaubine, previously isolated from Cabucala fasciculata (Titeux et al, 1975), Aspidosperma carapanauba (Giebert et al, 1963), and Rauwolfi a vomitoria (Amer and Court, 1980), respectively.…”

Section: N Hmentioning

confidence: 55%

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

Reina

Ruiz-Mesia

Mesia

et al. 2011

Zeitschrift Für Naturforschung C

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Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identifi ed as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specifi c cytotoxicity against mammalian cells were also determined.

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Leaf alkaloids of Rauwolfia vomitoria

Cited by 26 publications

References 15 publications

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of <i>Rauvolfia vomitoria</i> and <i>R. caffra</i>

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of <i>Rauvolfia vomitoria</i> and <i>R. caffra</i>

Chromosome constitution and alkaloid content in Rawolfia L.(Apocynaceae).

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

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Leaf alkaloids of Rauwolfia vomitoria

Cited by 26 publications

References 15 publications

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of &lt;i&gt;Rauvolfia vomitoria&lt;/i&gt; and &lt;i&gt;R. caffra&lt;/i&gt;

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of &lt;i&gt;Rauvolfia vomitoria&lt;/i&gt; and &lt;i&gt;R. caffra&lt;/i&gt;

Chromosome constitution and alkaloid content in Rawolfia L.(Apocynaceae).

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

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Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of <i>Rauvolfia vomitoria</i> and <i>R. caffra</i>

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of <i>Rauvolfia vomitoria</i> and <i>R. caffra</i>