Leading Causes of Cancer Mortality — Caribbean Region, 2003–2013

Razzaghi, Hilda; Quesnel-Crooks, Sarah; Sherman, Recinda; Joseph, Rachael; Kohler, Betsy A.; Andall‐Brereton, Glennis; Ivey, Marsha; Edwards, Brenda K.; Mery, Les; Gawryszewski, Vilma Pinheiro; Saraiya, Mona

doi:10.15585/mmwr.mm6549a3

Cited by 49 publications

(51 citation statements)

References 3 publications

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“…Lung cancer is one of the most common malignancies and the leading cause of cancer-related mortality worldwide (9). Approximately 80% of all lung cancer cases are non-small cell lung cancer (NSCLC) (10,11) and the majority of patients have been diagnosed in the advanced stage (12).…”

Section: Cytokine-induced Killer Cell Therapy For Modulating Regulatomentioning

confidence: 99%

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Previous studies have reported that regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self-tolerance, have a critical role in the regulation of the antitumor immune response. Targeting Tregs has the potential to augment cancer vaccine approaches. The current study therefore aimed to evaluate the role of cytokine-induced killer (CIK) cell infusion in modulating Tregs in patients with non-small cell lung cancer (NSCLC). A total of 15 patients with advanced NSCLC were treated by an infusion of CIK cells derived from autologous peripheral blood mononuclear cells (PBMCs). By using flow cytometry and liquid chip analysis, subsets of T cells and natural killer (NK) cells in peripheral blood, and plasma cytokine profiles in the treated patients, were analyzed at 2 and 4 weeks after CIK cell infusion. Cytotoxicity of PBMCs (n=15) and NK cells (n=6) isolated from NSCLC patients was evaluated before and after CIK cell therapy. Progression-free survival (PFS) and overall survival (OS) were also assessed. Analysis of the immune cell populations before and after treatment showed a significant increase in NK cells (P<0.05) concomitant with a significant decrease in Tregs (P<0.01) at 2 weeks post-infusion of CIK cells compared with the baseline. NK group 2D receptor (NKG2D) expression on NK cells was also significantly increased at 2 weeks post-infusion compared with the baseline (P<0.05). There was a positive correlation between NKG2D expression and the infusion number of CIK cells (P<0.05).

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Section: Cytokine-induced Killer Cell Therapy For Modulating Regulatomentioning

confidence: 99%

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

Wang

et al. 2017

Experimental and Therapeutic Medicine

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“…People of African Ancestry living in the US and Europe have the highest overall cancer incidence and mortality compared to other racial/ethnic groups 16 . Similarly people of African ancestry in the Caribbean and Latin American experience some of the highest cancer incidence and mortality worldwide 20,21 . Additionally, Africans in Africa suffer the greatest cancer-related mortality in the world 20,22 .…”

Section: Discussionmentioning

confidence: 99%

Cancer in populations of African Ancestry: studies of the African Caribbean Cancer Consortium

Ragin

Blackman

Roberts

et al. 2017

Cancer Causes Control

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“…In December 2016, Razzaghi et al 13 published an analysis in MMWR of cancer mortality in Caribbean islands using data taken directly from the Caribbean Public Health Agency (CARPHA) and without modeling adjustments. The publication presents an opportunity to understand the differences in cancer death estimation among the two modeled sources of IHME and IARC and the empiric data source of MMWR .…”

Section: Introductionmentioning

confidence: 99%

Age-Standardized Mortality Rates in the Caribbean: One Source, Three Different Interpretations

Wolf

Morgan

Flanigan

2018

JGO

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PurposeA recent publication in Morbidity and Mortality Weekly Report (MMWR) provided the opportunity to calculate differences in published cancer mortality estimates for Caribbean jurisdictions from three organizations: MMWR, the International Agency for Research on Cancer, and the Institute for Health Metrics and Evaluation. This comparison study serves to educate end users of these data.MethodsWe downloaded the publicly available cancer mortality estimates for 15 jurisdictions and the United States from the three organizations. We compared reported age-standardized mortality rates for each jurisdiction and calculated the range among estimates for each jurisdiction. We repeated this analysis after applying the same world population standard to all estimates.ResultsFor males, the ranges of the Caribbean estimates were between 49% (Grenada and Trinidad) and 201% (US Virgin Islands) of the MMWR value, with an average of 88%. For females, the ranges were between 15% (Trinidad) and 171% (US Virgin Islands) of the MMWR value, with an average of 64%. After all estimates were compared using the same population standard, the ranges of the Caribbean estimates for males were between 6% (Grenada) and 111% (US Virgin Islands) of the MMWR value, with an average of 34%. For females, the ranges were between 7% (Grenada) and 97% (US Virgin Islands), with an average of 28%.ConclusionThe use of different standard populations complicates comparisons across organizations. Data modeling does not completely compensate for quality of source data, as our analysis demonstrated by the differences in mortality rates despite the good quality of the vital registration in the Caribbean.

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Leading Causes of Cancer Mortality — Caribbean Region, 2003–2013

Cited by 49 publications

References 3 publications

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer

Cancer in populations of African Ancestry: studies of the African Caribbean Cancer Consortium

Age-Standardized Mortality Rates in the Caribbean: One Source, Three Different Interpretations

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