Lead Systems

Limb Lead Interchange in Thorough QT/QTc Studies

“…Nilsson et al 20 recently reported that a commercially available electrocardiograph could detect 38% of the limb lead reversals in 53 875 ECGs. Most rule-based models detect only RA-LA electrode reversal 21,22 and cannot identify other combinations of interchange 9,12 ; in our study the electrocardiograph identified RA-LA interchange in only 57.1% of cases. These automated algorithms are also programmed to diagnose other ECG abnormalities, and in the presence of limb interchange, they may make incorrect diagnoses like ectopic atrial rhythm, accelerated junctional rhythm, 23 intraventricular conduction disturbance, 24,25 chamber enlargement, ventricular preexcitation, 26 and myocardial ischemia/infarction [27][28][29][30] in an essentially normal ECG.…”

Estimation performance of a reduced lead system during continuous 12-lead ECG ST-segment monitoring

“…4,6,[17][18][19] However, references to evidence supporting this are seldom provided (for example refer to 6,17 ). Furthermore, the evidence provided is largely based on experiments which did not reflect changes in the cardiac electrical activity (for example refer to 4,18,19 ). Based on an extensive review of literature, only one published study 20 1 GEN b.001 a b.557 that assessed the estimation performance of the I, II, V2 and V5 during ischemic-type ECG changes was identified.…”

Optimisation of Electrode Placement for New Ambulatory ECG Monitoring Devices

“…What remains to be tested is the performance of the R-lead during events of myocardial ischemia. This will be of interest as BCLs CS5 and CM5 have been previously been described to detect up to 90% of all ST segment depression identified by multi-lead ECG systems [2][16].…”

“…Given the described improvement in lead-vector magnitude from BCLs [2], this may make them an appropriate choice for single-lead ambulatory ECG monitors focused on assessing cardiac rhythm. …”

“…If the arrhythmia is not diagnosed on the 12-lead ECG, which can be the case with patients experiencing short intermittent arrhythmic episodes, continuous ambulatory ECG monitoring is usually performed. Ambulatory monitoring can be used for a number of different reasons, the most common being for the investigation of cardiac rhythm [2]. Over the past decade a number of new and novel devices for continuous ambulatory ECG monitoring have emerged.…”