LEAD POISONING&lt;subtitle&gt;Observations in Fourteen Cases&lt;/subtitle&gt;

Giannattasio, R C; Bedo, Andrew V.; Pirozzi, Michael

doi:10.1001/archpedi.1952.02050030042003

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…Half of the workers (10 of 20) had elevated PbB levels (60 to 120 )JLg/dL) and showed definite electromyographic deficits. Overt symptoms of encephalopathy similar to those that occur in adults have been reported to occur in infants and young children (Prendergast, 1910;Blackfan, 1917;McKhann and Vogt, 1926;Giannattasio et al, 1952;Cumings, 1959;Tepper, 1963;Chisolm, 1968). Hemberg (1980, 1982) have confirmed a dose-dependent slowing of NCV in lead workers with PbB levels below 70 to 80 )JLg/dL.…”

Section: Non-carcinogenic Effectsmentioning

confidence: 88%

Lead Health Effects in Drinking Water

Marcus

1986

Toxicol Ind Health

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The quantification of toxicological effects of a chemical consists of an assessment of the non-carcinogenic and carcinogenic effects. In the quantification of non-carcinogenic effects, an Acceptable Daily Intake (ADI) is calculated. An Adjusted Acceptable Daily Intake (AADI) and Health Advisory (HA) values for the chemical are then calculated to define the appropriate drinking water concentrations to limit human exposure. For ingestion data, this approach is illustrated as follows:where: NOAEL = no-observed-adverse-effect level. LOAEL = lowest-observed-adverse-effect level.Body weight = 70 kg for adult or 10 kg for child. Drinking water volume = 2 L per day for adults or 1 L per day for children. Uncertainty/Safety Factor = 10, 100 or 1,000.

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Section: Non-carcinogenic Effectsmentioning

confidence: 88%

Lead Health Effects in Drinking Water

Marcus

1986

Toxicol Ind Health

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Effects of inorganic lead in vitro on ion exchanges and respiratory metabolism of rat kidney cortex

1985

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The effects of Pb2+ added in vitro to tissue slices, isolated tubules and isolated mitochondria of rat kidney cortex have been studied. Slices were depleted of K+ and loaded with Na+, Cl- and water by pre-incubation at 1 degree C, and reversal of these changes was then induced by incubation under metabolically favourable conditions. The net reaccumulation of K+ was reduced by a maximum of 30% when Pb2+ was present in the medium, the maximal effect being caused by 200 microM Pb2+. Lead also caused a reduction of Na+ extrusion which was approximately equimolar with its effect on K+, but it did not affect the extrusion of Cl- and water. The initial rates of the net, active movements of K+ and Na+ were not altered by Pb2+, divergence from control values only being noted after 15-30 min incubation. The O2 consumption and the ATP content were 25-30% lower in slices incubated with 200 microM Pb2+ than in control slices; the effect on ATP content was not observed until incubation had continued for 30 min. In tubules isolated from the renal cortex, the rate of respiration (50%) and ATP content (30%) were also partly reduced by 200 microM Pb2+. The consumption of O2 by mitochondria isolated from the cortex was much more sensitive to Pb2+ added in vitro than the respiration of intact cells; the rate of respiration in state 3 (presence of phosphate acceptor) and the respiratory control ratio were drastically reduced, with half-maximal inhibition at 30 and 20 microM Pb2+ respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Urinary excretion of amino acids by men absorbing heavy metals

Clarkson

Kench

1956

Biochemical Journal

159

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ISOLATION OF PHOSPHOARGININE 361 tained in the crystalline state (needles), but is unstable even in the dry condition; the Na and K salts have been isolated but are extremely hygroscopic and therefore of little value; the Li salt is quite stable, but was difficult to prepare in good yield and could not be crystallized. However, it has been found that the Ba may be removed from BaPA by the addition of Na2SO4 and that after several washings of the BaSO4 a quantitative recovery of the phosphoarginine may be obtained. SUMMARY 1. A method is described for the isolation in good yield (10 g./kg.) of phosphoarginine from the muscle of crayfish. 2. The compound was isolated as a barium salt, free from contaminating material and corresponding to the formula C6H.305N4PBa,H2CO3,H20.

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LEAD POISONING<subtitle>Observations in Fourteen Cases</subtitle>

Cited by 5 publications

References 3 publications

Lead Health Effects in Drinking Water

Lead Health Effects in Drinking Water

Effects of inorganic lead in vitro on ion exchanges and respiratory metabolism of rat kidney cortex

Urinary excretion of amino acids by men absorbing heavy metals

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