Abstract:Lead (Pb) poisoning during early development is associated with behavioral and cognitive deficits, but the specific mechanisms by which Pb impairs brain development are not fully understood. One potential mechanism is that Pb poisoning may impair thyroid hormone (TH)-mediated changes in brain development. To address this issue, we performed experiments to assess the effects of Pb poisoning on (TH)-dependent changes in cellular and molecular mechanisms in the developing Xenopus laevis tadpole brain. We treated … Show more
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