Lead nephrotoxicity and associated disorders: biochemical mechanisms

Nolan, Canice; Shaikh, Zahir A.

doi:10.1016/0300-483x(92)90097-x

Cited by 149 publications

(109 citation statements)

References 108 publications

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“…36 Chronic nephropathy from lead exposure often shows interstitial fibrosis and cystic hyperplasia in humans and animals. 2,9,37,38 Lead is also a renal carcinogen in animals 14,39 and possibly in humans. 1 The profound nephrotoxicity induced by lead is characterized by cellular inclusion bodies and renal tubular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…1 Toxic effects of lead occur in multiple organ systems but particularly the developing nervous system of infants and children. 2,3 Renal effects are also common in adults with chronic lead exposure. 3 Lead produces renal tumors in rodents, and lead and inorganic lead compounds have been classified as possible human carcinogens.…”

mentioning

confidence: 99%

“…5,7,8 Lead-induced inclusion bodies are frequently nuclear, roughly spherical, and typically consist of an electron-dense core with a fibrillary network at the periphery. 2 These inclusion bodies, although common in the kidney, also form in cells of nervous tissue origin such as astrocytes, 9 neuroblastoma cells, 10 and in other cell types such as osteoclasts. 11 Metal analysis shows that lead is highly concentrated within the inclusion bodies.…”

mentioning

confidence: 99%

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The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

Qu¹,

Diwan²,

Liu³

et al. 2002

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

Qu¹,

Diwan²,

Liu³

et al. 2002

The American Journal of Pathology

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“…It is being increasingly acknowledged that kidney damage is not only associated with dosage, but also with the duration of exposure to lead sources. Prolonged or repeated exposure is thought to increase clinical manifestations, most often occurring with blood lead concentrations greater than 40 mg/dl (Nolan and Shaikn, 1992). The monitoring of chronic conditions in the population of Santa Maria Atzompa is an ongoing project.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with lead exposure in Oaxaca, Mexico

Isidra

Rojas

et al. 2003

J Expo Sci Environ Epidemiol

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Lead intoxication risks were studied in a community of ceramic folk art workers in Oaxaca, a southern state of Mexico, where the manufacture of lowtemperature lead ceramic ware is a family tradition and often the only source of income. Variables such as household characteristics, occupation, and lead exposure risk factors were explored. Study participants' mean blood lead concentration was 43.8 mg/dl (range ¼ 8.4-99.6 mg/dl), which is over the WHO guideline of 40 mg/dl for removing workers from exposure and is the concentration over which renal damage is accelerated. Best predictors for high blood lead concentrations by multivariable regression analysis were: occupation (Po0.0001), gender (P ¼ 0.0002), and the use of glazed stoneware (Po0.0001). This model explained 18% of blood lead variation among the study group. Exposure appears to be primarily associated with antiquated pottery manufacturing techniques and the high degree of contamination prevailing at the production sites, which in most cases are their living quarters. This consequently affects the lead levels of the entire community.

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“…Several heavy metals can bind to sulphydrilic, aminic, and carboxylic groups of membrane proteins, so modifying membrane structure and permeability (Victery et al, 1984;HerakKramberger and Sabolic, 2001). Moreover they can induce oxidative stress (Koizumi et al, 1996;Pourahmad et al, 2003), cell proliferation and tumour production in renal tubules (Nolan and Shaikhu, 1992), necrosis and apoptosis with successive compensative regeneration (Tanimoto et al, 1993;Hamada et al, 1996;Bomhard et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cell‐cycle protein modifications in the kidney of Mus spretus from Doñana National Park

Leoni

Torrice

Chiuchiarelli

et al. 2008

Environmental Toxicology

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On April 1998 a tailing dam of the Aznalcollar pyrite mine partially collapsed and released to the Guadiamar river acidic water and mud containing toxic metals threatening the Doñ ana National Park, a Spanish wildlife reserve located near the estuary of Guadalquivir river. To assess the possible biological effects on terrestrial ecosystems, biochemical markers were assayed in the kidneys of Algerian mice (Mus spretus) collected in several areas of Doñ ana and Guadiamar river. Biomarkers assayed are proteins involved in cell cycle regulation, in particular cyclins and their associated kinases, and some cell cycle inhibitors. Moreover Mitogen Activated Protein Kinases (MAPK), a signal transduction system involved in cell division, p53, a protein involved in growth arrest after DNA damage, and HSP70, an early stressinduced protein, were assayed. The kidneys of animals collected one year after the ecological disaster had increased levels of PCNA (proliferating cell nuclear antigen), indicating an increased number of cells in the S phase of cell cycle. This shift of cells from G0 to S phase is due to increased levels of cyclins D1, E, and A, to decreased levels of p21 and p27 cdk inhibitors, and to activation of MAPK cascade. On the other hand, p53 and HSP70 levels are not changed. These data demonstrate that the presence of toxic metals after ecological disaster provoked the induction of kidney cell proliferation interpretable as a compensatory cell growth after tissue damage and apoptosis, and that could lead to the genomic instability characteristic of cancer cell. # 2008 Wiley Periodicals, Inc. Environ Toxicol 23: 44-51, 2008

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Lead nephrotoxicity and associated disorders: biochemical mechanisms

Cited by 149 publications

References 108 publications

The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies

Factors associated with lead exposure in Oaxaca, Mexico

Cell‐cycle protein modifications in the kidney of Mus spretus from Doñana National Park

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