Lead intoxication caused by skeletal disease

Berlin, Kurt; Gerhardsson, Lars; Börjesson, Johan; Lindh, Erik; Lundström, Nils-Göran; Schütz, Andrejs; Skerfving, Staffan; Edling, Chister

doi:10.5271/sjweh.42

Cited by 41 publications

(29 citation statements)

References 22 publications

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“…In physiological and pathological states such as pregnancy, lactation, and osteoporosis, mobilization of lead from the bone reservoir may occur (8,14,15). In two case reports lead poisoning in thyrotoxicosis was described in formerly lead-exposed subjects (6,7).…”

Section: Discussionmentioning

confidence: 98%

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Increased Lead Excretion Correlates with Desoxypyridinoline Crosslinks in Hyperthyroid Patients

Osterode

Reining²,

Manner³

et al. 2000

Thyroid

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Lead is a widespread toxic metal that accumulates predominantly in human bone. Altered bone metabolism in hyperthyroidism is characterized mainly by bone resorption. Thus, we speculated that lead excretion could be increased in hyperthyroid patients. In 12 hyperthyroid patients (43.3 +/- 16.1 years) who were not previously occupationally exposed to lead, lead concentrations in blood (PbB), spot urine samples corrected by urine creatinine (PbUs), and in 24-hour urine samples (PbU24) were determined in the hyperthyroid state and after euthyroidism had been induced by therapy. Serum osteocalcin (OC) and desoxypyridinoline crosslinks (Pyr) served as specific markers for bone metabolism. After induction of euthyroidism (duration of antithyroid therapy: mean 17.3 +/- 6.9 weeks) PbB was reduced (3.7 +/- 2.6 vs. 5.7 +/- 4.7 microg/dL, p = 0.041) as was PbUs (0.39 +/-0.27 vs. 0.61 +/- 0.32 microg/mg Cr, p = 0.005). A fourfold decrease of PbU24 was associated with a 3.3-fold decrease of Pyr, and moreover there was a significant correlation between Pyr and PbUs (r = 0.58, p = 0.047). Concentration of total triiodothyronine correlated with Pyr (r = 0.66, p = 0.018), but not with PbB or PbUs. OC showed only a tendency to be increased before antithyroid medication, and did not correlate with either thyroid hormone or Pyr. Our results indicate that in hyperthyroid patients, even when not previously exposed to lead, lead excretion is increased due to bone resorption.

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Section: Discussionmentioning

confidence: 98%

“…In these cases treatment of hyperthyroidism has been shown to decrease blood lead concentrations (6,7). Lead intoxication was also observed in patients with skeletal diseases such as osteoporosis, and it was suspected that a moderately increased bone lead pool and skeletal disease may increase the risk of lead poisoning (8).…”

Section: Introductionmentioning

confidence: 98%

Increased Lead Excretion Correlates with Desoxypyridinoline Crosslinks in Hyperthyroid Patients

Osterode

Reining²,

Manner³

et al. 2000

Thyroid

View full text Add to dashboard Cite

show abstract

“…HRT, alone or combined, prevents bone resorption and increases the BMD in trabecular and cortical bones of women with and without metabolic bone disease (Berlin et al 1995;Gruber et al 1997;Webber et al 1995). This effect may lead to a decrease of lead mobilization from bone together with a reduction in blood lead levels.…”

Section: Discussionmentioning

confidence: 99%

“…Suspicion exists that the accumulation of lead in bone itself represents a risk factor for osteoporosis. Individual cases such as the subjects reported by Berlin et al (1995) who had occupational lead exposure, a bone fracture, and diagnosis of idiopathic osteoporosis provide some circumstantial evidence of such a relationship. Other evidence supporting the hypothesis that lead can directly damage bone includes observations of fetal and neonatal growth reduction and the development of osteopenia in experimental animals exposed to lead (Gruber et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Blood and Bone Lead to Menopause and Bone Mineral Density among Middle-Age Women in Mexico City

Latorre¹,

Hernández-Ávila²,

Orozco³

et al. 2002

Environ Health Perspect

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“…Under conditions in which the individual's body burden of lead is higher than that typical of the current environment, the predicted PbB concentrations could be dominated by PbBone stores. For example, Berlin et al (22) (33).…”

Section: Dose Response To Leadmentioning

confidence: 99%