Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm

Hsu, Ping Chi; Liu, Ming Yie; Hsu, Chao Chin; Chen, Lih Yuh; Guo, Yang

doi:10.1016/s0300-483x(97)00090-5

Cited by 98 publications

(58 citation statements)

References 33 publications

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“…A report demonstrated that Pb exposure stimulated ROS generation in rat spermatozoa, which was negatively correlated with fertility (Hsu et al, 1997). Pb exposure might descend defense ability of sperm to the oxidative stress and enhance the ROS generation, reduce sperm motility and oocyte penetration capability in rat (Hsu et al, 1998).…”

Section: Leadmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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Section: Leadmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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“…Using an assay based on the chemiluminescent signal produced from the reaction of luminol with ROS, Hsu et al (225) found that sperm from lead-exposed rats had increased ROS levels that were inversely correlated with sperm count, motility, and oocyte penetration rate. The mechanism of the formation of ROS by lead has not been resolved.…”

Section: Oxidative Stress and Dna Damage In Spermmentioning

confidence: 99%

Understanding the human health effects of chemical mixtures.

Carpenter

Arcaro

Spink

2002

Environ Health Perspect

323

198

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Most research on the effects of chemicals on biologic systems is conducted on one chemical at a time. However, in the real world people are exposed to mixtures, not single chemicals. Although various substances may have totally independent actions, in many cases two substances may act at the same site in ways that can be either additive or nonadditive. Many even more complex interactions may occur if two chemicals act at different but related targets. In the extreme case there may be synergistic effects, in which case the effects of two substances together are greater than the sum of either effect alone. In reality, most persons are exposed to many chemicals, not just one or two, and therefore the effects of a chemical mixture are extremely complex and may differ for each mixture depending on the chemical composition. This complexity is a major reason why mixtures have not been well studied. In this review we attempt to illustrate some of the principles and approaches that can be used to study effects of mixtures. By the nature of the state of the science, this discussion is more a presentation of what we do not know than of what we do know about mixtures. We approach the study of mixtures at three levels, using specific examples. First, we discuss several human diseases in relation to a variety of environmental agents believed to influence the development and progression of the disease. We present results of selected cellular and animal studies in which simple mixtures have been investigated. Finally, we discuss some of the effects of mixtures at a molecular level.

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“…Pb +2 binding to sulfhydryl groups can reduce GSH levels and can interfere with its antioxidant activity [18]. However, alterations of SOD and GPx activities were not significant in lead-exposed group in comparison to control group that is different to some extent from previously published results [29,30].…”

Section: Discussionmentioning

confidence: 77%

“…Beneficial effects of some antioxidant compounds in reducing toxic effects of lead have been reported [30]. Pande et al [22] demonstrated that lead-induced MDA production was decreased by 30% -40% after supplementation with antioxidants.…”

Section: Discussionmentioning

confidence: 98%

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Lotfi-Ghahramanloo

Baghshani

2016

Zahedan J Res Med Sci

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Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm

Cited by 98 publications

References 33 publications

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Understanding the human health effects of chemical mixtures.

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

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