Lead exposure and increased food allergic sensitization in U.S. children and adults

Mener, David J.; García‐Esquinas, Esther; Navas‐Acien, Ana; Dietert, Rodney R.; Shargorodsky, Josef; Lin, Sandra Y.

doi:10.1002/alr.21460

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…Pb is extremely dangerous and affects the entire organism. It accumulates in different tissues and organs, causing different diseases ranging from mental retardation, brain damage, autism, and dyslexia to allergies, paralysis, muscular weakness, and kidney damage [ 27 , 49 , 56 , 57 , 58 , 59 , 60 ]. Nonetheless, lead toxicity is the primary cause of disease outcome for many organs, and it even causes death [ 27 ].…”

Section: Air Pollution: the Role Played By Particulate Matter And mentioning

confidence: 99%

“…Two years of Pb exposure causes chronic nephropathy manifested by focal atrophy, loss of proximal tubules, and intestinal fibrosis [ 56 ]. Continued exposition to Pb may also have immunotoxic effect and in adults it is associated with sensitization to food allergens [ 57 ]. Interestingly, an increase in Pb blood levels of adult subjects is associated with increased sensitization to food allergens, with odds ratio 1.11; 95% confidence interval 1.02 to 1.22 [ 57 ].…”

Section: Air Pollution: the Role Played By Particulate Matter And mentioning

confidence: 99%

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Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Finicelli

Squillaro

Galderisi

et al. 2020

IJMS

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Environmental pollution has reached a global echo and represents a serious problem for human health. Air pollution encompasses a set of hazardous substances, such as particulate matter and heavy metals (e.g., cadmium, lead, and arsenic), and has a strong impact on the environment by affecting groundwater, soil, and air. An adaptive response to environmental cues is essential for human survival, which is associated with the induction of adaptive phenotypes. The epigenetic mechanisms regulating the expression patterns of several genes are promising candidates to provide mechanistic and prognostic insights into this. Micro-RNAs (miRNAs) fulfil these features given their ability to respond to environmental factors and their critical role in determining phenotypes. These molecules are present in extracellular fluids, and their expression patterns are organ-, tissue-, or cell-specific. Moreover, the experimental settings for their quantitative and qualitative analysis are robust, standardized, and inexpensive. In this review, we provide an update on the role of miRNAs as suitable tools for understanding the mechanisms behind the physiopathological response to toxicants and the prognostic value of their expression pattern associable with specific exposures. We look at the mechanistic evidence associable to the role of miRNAs in the processes leading to environmental-induced pulmonary disease (i.e., chronic obstructive pulmonary disease).

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Section: Air Pollution: the Role Played By Particulate Matter And mentioning

confidence: 99%

Section: Air Pollution: the Role Played By Particulate Matter And mentioning

confidence: 99%

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Finicelli

Squillaro

Galderisi

et al. 2020

IJMS

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“…The impact of allergies is the decreased quality of life, increased medical costs, impaired concentration, growth and development (Sudewi et al, 2009). Previous research conducted in Medan, North Sumatera, reported that air lead levels in industrial areas in Medan had exceeded the threshold value from the government which was 2μg/m (Mener et al, 2014;Pawankar et al, 2013;Sudewi et al, 2009;Girsang, 2008). The objective of this study is to determine the correlation between blood lead levels and total immunoglobulin E level in primary school children.…”

Section: Introductionmentioning

confidence: 95%

“…The toxic effects in children can arise from the lowest level of lead concentration at 5 μg/dL to the lethal concentration at about 150 μg/dL. According to the Center for Disease Control and Prevention (CDC) the toxic effect of lead can be observed at the serum level of 5 μg/dL (Farias et al, 2014;Mener et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The immune system is particularly sensitive to lead poisoning. Lead is immunotoxic even at a very low level (Mener et al, 2014). Lead will shift T-helper 1 (Th1) dependent immunity toward T-helper 2 (Th2) dependent immunity resulting in increasing allergic sensitization through increasing production of interleukins, cytokines, and immunoglobulin E (IgE) (Mener et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Lead Serum Level and Total Immunoglobulin E(Ige) Level in School-Aged Children

2018

European Journal of Medicine

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Correlation between lead serum level and total Immunoglobulin E (IgE) level in school-aged children. Gusmira Y.H., Irsa, L., Lubis, B., Evalina, R., Lubis, M. Lead poisoning may cause various health problems including immune system. Research objective is to determine the correlation between serum lead levels with total IgE level in school-aged children. A cross sectional study had been conducted in Juli 2015 to children aged 9-12 years old in an elementary school industrial area with lead exposure, Medan, Sumatera Utara. Children with atopy and worm infection were excluded. Lead serum level and total immunoglobulin E level were obtained. Data analysis to see correlation between blood lead level and total IgE level was used Pearson correlation test (r) if normal data distribution and Spearman test if abnormal data distribution with significance level P <0.05. From 42 subjects, 27 were boys and 15 girls, the mean age was 10.3 year (SD 1.09), 18 subjects with medium risk of allergic. The mean serum lead level was 2.57 μg/dL (SD 0.58, 95 %CI 2.42-2.74), the mean IgE total level was 1155 IU/L (SD 3340, 95%CI114.43-2196.22). From the Spearman test we obtained r= 0.023, p=0.887. It can be concluded that here was an increase in total IgE levels and blood lead levels but statistically no correlation between lead serum level and total IgE level among school aged children.

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Editorial

Toskala¹

2015

Int Forum Allergy Rhinol

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Lead exposure and increased food allergic sensitization in U.S. children and adults

Abstract: Exposure to lead was associated with increased odds of sensitization to food allergens in adult but not children participants.

Cited by 14 publications

References 31 publications

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Correlation between Lead Serum Level and Total Immunoglobulin E(Ige) Level in School-Aged Children

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