Lead Discovery of α,β‐Unsaturated Sulfones from a Combinatorial Library as Inhibitors of Inducible VCAM‐1 Expression.

Abstract

Medicinal chemistryMedicinal chemistry V 1100 Lead Discovery of α,β-Unsaturated Sulfones from a Combinatorial Library as Inhibitors of Inducible VCAM-1 Expression. -Conjugation of the sulfonyl group in title compounds (I) to a vinyl group, cf. derivative (Ie), increases the potency dramatically. -(NI, L.; ZHENG, X. S.; SOMERS, P. K.; HOONG, L. K.; HILL, R. R.; MARINO, E. M.; SUEN, K.-L.; SAXENA, U.; MENG*, C. Q.; Bioorg. Med. Chem. Lett. 13 (2003) 4, 745-748; AtheroGenics, Inc., Alpharetta, GA 30004, USA; Eng.) -M. Schroeter 24-209