Abstract:Medicinal chemistryMedicinal chemistry V 1100 Lead Discovery of α,β-Unsaturated Sulfones from a Combinatorial Library as Inhibitors of Inducible VCAM-1 Expression. -Conjugation of the sulfonyl group in title compounds (I) to a vinyl group, cf. derivative (Ie), increases the potency dramatically. -(NI, L.; ZHENG, X. S.; SOMERS, P. K.; HOONG, L. K.; HILL, R. R.; MARINO, E. M.; SUEN, K.-L.; SAXENA, U.; MENG*, C. Q.; Bioorg. Med. Chem. Lett. 13 (2003) 4, 745-748; AtheroGenics, Inc., Alpharetta, GA 30004, USA; Eng.… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.