To
identify U.S. lead exposure risk hotspots, we expanded upon
geospatial statistical methods from a published Michigan case study.
The evaluation of identified hotspots using five lead indices, based
on housing age and sociodemographic data, showed moderate-to-substantial
agreement with state-identified higher-risk locations from nine public
health department reports (45–78%) and with hotspots of children’s
blood lead data from Michigan and Ohio (e.g., Cohen’s kappa
scores of 0.49–0.63). Applying geospatial cluster analysis
and 80th–100th percentile methods to the lead indices, the
number of U.S. census tracts ranged from ∼8% (intersection
of indices) to ∼41% (combination of indices). Analyses of the
number of children <6 years old living in those census tracts revealed
the states (e.g., Illinois, Michigan, New Jersey, New York, Ohio,
Pennsylvania, Massachusetts, California, Texas) and counties with
highest potential lead exposure risk. Results support use of available
lead indices as surrogates to identify locations in the absence of
consistent, complete blood lead level (BLL) data across the United
States. Ground-truthing with local knowledge, additional BLL data,
and environmental data is needed to improve identification and analysis
of lead exposure and BLL hotspots for interventions. While the science
evolves, these screening results can inform “deeper dive”
analyses for targeting lead actions.