Lead concentration in the bladder tissue and blood of patients with bladder cancer

Gołąbek, Tomasz; Darewicz, Barbara; Borawska, Maria H.; Maciejewski, Ryszard; Socha, Katarzyna; Kudelski, Jacek

doi:10.3109/00365590903198991

Cited by 19 publications

(8 citation statements)

References 28 publications

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“…It has been suggested that chronic bladder irritation, decreased urinary washout effect, atrophic involution of the bladder, 8 compound abuse of analgesics, 15 usage of Chinese herbs, 16 consumption of contaminated groundwater 17,18 and uraemia per se 4,8 may play roles in the development of TCC. Furthermore, possible associations between lead or cadmium exposure and development of bladder cancer have been demonstrated 19,20 . In previous studies, we have also reported that environmental exposure to lead 21–23 or cadmium 24 remains a serious health problem in Taiwanese patients undergoing chronic dialysis.…”

mentioning

confidence: 89%

High incidence and recurrence of transitional cell carcinoma in Taiwanese patients with end‐stage renal disease

Wang

Kuo

et al. 2011

Nephrology

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confidence: 89%

High incidence and recurrence of transitional cell carcinoma in Taiwanese patients with end‐stage renal disease

Wang

Kuo

et al. 2011

Nephrology

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“…Lead is classified as a probable carcinogen (Group 2A) by the International Agency for Research on Cancer (IARC) based on sufficient animal data and limited human data (IARC, 2006). Thus far, epidemiological studies evaluating lead exposure and cancer risk have been inconclusive (IARC, 2006; Fu and Boffetta, 1995; Jemal, et al, 2002; Steenland and Boffetta, 2000), although recently there is more consistent evidence for increased risk of cancers of the stomach, brain, urinary bladder and kidney with lead exposure (Bhatti, et al, 2009; Boffetta, et al, 2011; Cocco, et al, 1998; Golabek, et al, 2009; Rajaraman, et al, 2006; Rousseau, et al, 2007; van Bemmel, et al, 2011; van Wijngaarden and Dosemeci, 2006). Given the widespread degree of lead exposure and the difficulty in evaluating rare diseases such as brain and kidney cancers in industry-based studies, it is important to improve exposure assessment for general population and case-control studies to generate new evidence.…”

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confidence: 99%

Calibrating a population-based job-exposure matrix using inspection measurements to estimate historical occupational exposure to lead for a population-based cohort in Shanghai, China

Koh

Bhatti

Coble

et al. 2012

J Expo Sci Environ Epidemiol

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The epidemiologic evidence for the carcinogenicity of lead is inconsistent and requires improved exposure assessment to estimate risk. We evaluated historical occupational lead exposure for a population-based cohort of women (n=74,942) by calibrating a job-exposure matrix (JEM) with lead fume (n=20,084) and lead dust (n=5,383) measurements collected over four decades in Shanghai, China. Using mixed-effect models, we calibrated intensity JEM ratings to the measurements using fixed-effects terms for year and JEM rating. We developed job/industry-specific estimates from the random-effects terms for job and industry. The model estimates were applied to subjects’ jobs when the JEM probability rating was high for either job or industry; remaining jobs were considered unexposed. The models predicted that exposure increased monotonically with JEM intensity rating and decreased 20–50-fold over time. The cumulative calibrated JEM estimates and job/industry-specific estimates were highly correlated (Pearson correlation=0.79–0.84). Overall, 5% of the person-years and 8% of the women were exposed to lead fume; 2% of the person-years and 4% of the women were exposed to lead dust. The most common lead-exposed jobs were manufacturing electronic equipment. These historical lead estimates should enhance our ability to detect associations between lead exposure and cancer risk in future epidemiologic analyses.

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“…Other studies on the carcinogenic mechanisms of Cr, Ni and Pb in the bladder are scant. Several clinical studies have attempted to quantify the levels of heavy metals in tumoral lesions and the adjacent normal parts of various organs in the urinary system; however, the results were controversial …”

Section: Discussionmentioning

confidence: 99%

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

Chang

Liu

et al. 2015

Int J of Urology

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Objectives: To evaluate possible sources of exposure to heavy metals in the general population, and to determine the association between urinary heavy metals and urothelial carcinoma risk. Methods: We recruited 205 patients with urothelial carcinoma and 406 control participants for a case-control study between June 2011 and December 2013. The control participants were frequency-matched with cases according to sex and age. We measured the urinary levels of arsenic, cadmium, chromium, nickel and lead by using inductively coupled plasma mass spectrometry. We collected environmental exposurerelated information through questionnaires. Multivariate logistic regression and 95% confidence intervals were applied to estimate the urothelial carcinoma risk and potential effects of urothelial carcinoma-related risk factors on the levels of urinary heavy metals. Results: Patients with urothelial carcinoma showed higher urinary levels of arsenic, cadmium, chromium, nickel and lead than the controls. After considering other potential risk factors, a significantly increased risk for urothelial carcinoma was observed in patients with increased urinary levels of cadmium, chromium, nickel and lead. Smokers showed a high urinary cadmium level. In addition to cadmium, a high urinary lead level was associated with cumulative cigarette smoking and herbal medicine use. Conclusion: Environmental factors might contribute to higher urinary levels of heavy metals and ultimately result in urothelial carcinoma carcinogenesis. These findings can promote proper environmental surveillance of exposure to heavy metals in the general population.

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Lead concentration in the bladder tissue and blood of patients with bladder cancer

Abstract: The results suggest that there is a relationship between exposure to lead and the initialization and development of bladder cancer.

Cited by 19 publications

References 28 publications

High incidence and recurrence of transitional cell carcinoma in Taiwanese patients with end‐stage renal disease

High incidence and recurrence of transitional cell carcinoma in Taiwanese patients with end‐stage renal disease

Calibrating a population-based job-exposure matrix using inspection measurements to estimate historical occupational exposure to lead for a population-based cohort in Shanghai, China

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

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