Lead Compounds from Mangrove-Associated Microorganisms

Ancheeva, Elena; Δαλέτος, Γεώργιος; Proksch, Peter

doi:10.3390/md16090319

Cited by 64 publications

(50 citation statements)

References 94 publications

(111 reference statements)

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“…Due to the special ecologic niche of mangroves, the ability of secondary metabolites of microorganisms is given to conquer harsh habitats. Most biosynthetic gene clusters of secondary metabolites are silent under standard laboratory culture conditions, new methods are needed to activate gene expression for metabolism exploration [59]. Our genomic analysis results here can provide guidance for gene regulation and facilitate the further studies of secondary metabolites in P. variabile.…”

Section: Functional Categorizationmentioning

confidence: 92%

Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1

Peng¹,

Li²,

Liu³

et al. 2019

JoF

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Penicillium is an ascomycetous genus widely distributed in the natural environment and is one of the dominant fungi involved in the decomposition of mangroves, which can produce a variety of antitumor compounds and bioactive substances. However, in mangrove ecosystems there is no complete genome in this genus. In this study, we isolated a fungus strain named Penicillium variabile HXQ-H-1 from coast mangrove (Fujian Province, China). We generated a chromosome-level genome with total size of 33.32 Mb, scaffold N50 of 5.23 Mb and contig N50 of 96.74 kb. Additionally, we anchored about 95.91% assembly sequences into the longest seven scaffolds, and predicted 10,622 protein-coding genes, in which 99.66% could be annotated by eight protein databases. The secondary metabolites analysis reveals the strain has various gene clusters involving polyketide synthase (PKS), non-ribosomal peptide synthetase (NRPS) and terpene synthase that may have a largely capacity of biotechnological potential. Comparison genome analysis between Penicillium variabile and Talaromyces islandicus reveals a small difference in the total number of genes, whereas HXQ-H-1 has a higher gene number with COG functional annotation. Evolutionary relationship of Penicillum based on genome-wide data was carried out for the first time, showing the strain HXQ-H-1 is closely related to Talaromyces islandicus. This genomic resource may provide a new resource for development of novel bioactive antibiotics, drug candidates and precursors in Penicillium variabile.

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Section: Functional Categorizationmentioning

confidence: 92%

Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1

Peng¹,

Li²,

Liu³

et al. 2019

JoF

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“…Mangrove forest has emerged as a rich store of chemically diverse natural products [17] -any small molecules produced by living organisms [18,69] . Strategically positioned between terrestrial and marine ecosystem, mangrove forest represents a rare habitat of living organisms capable of thriving in extreme environmental conditions -saline, acidic and fluctuating tides [70] .…”

Section: Discussionmentioning

confidence: 99%

“…underexplored habitats such as mangroves, as sources of biologically active compounds [14][15][16] . For instance, the review by Ancheeva and colleagues highlighted that between the years of 2014 and 2018, 163 compounds isolated mostly from mangrove-derived fungi, exhibited potent anti-cancer, antimicrobial, anti-inflammatory, cholesterol lowering and α-glucosidase activity [17] . Also, from year 2000 and onwards, microbial natural products, particular from bacteria, have accounted for 8.9 % of all the Food and Drug Administration-approved new molecular entity (NME) compared to 5.6 % that make up plant-based FDA-approved NME [18] .…”

Section: Introductionmentioning

confidence: 99%

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

Kemung¹,

Tan²,

Chan³

et al. 2019

Prog Drug Discov Biomed Sci

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Streptomyces are a distinguished group of gram-positive bacteria mostly acknowledged for their immense contribution to life-saving drugs and lines of compounds with diverse bioactivities. To date, there remains limited studies on Streptomyces with biological activities residing in underexplored ecosystems such as the mangrove forests. For this purpose, the present work aimed at investigating the biological activity of Streptomyces sp. MUSC 11 collected from soil sample in mangrove forests, situated in the State of Pahang, Peninsular of Malaysia. The cultured strain resembled phenotypic and genotypic traits of genus Streptomyces. Investigations of the methanolic extract from Streptomyces sp. MUSC 11 revealed antioxidant activities in form of scavenging free radicals ABTS, DPPH, chelating iron and reducing ferric iron. Besides the antioxidant tests, antioxidant results corresponded well to the presence of phenolic content. In summary, Streptomyces derived from extreme and understudied ecosystem such as the mangrove forests are potential sources of biologically active and therapeutically useful compounds.

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“…Mangrove endophytic fungi are attracting considerable attention from natural product chemists and biologists alike and a great deal of structurally diverse natural products with unusual biological activity have been discovered recently [ 1 , 2 , 3 ]. Fungal genera Alternaria , Aspergillus , Cladosporium , Colletotrichum , Fusarium , Paecilomyces , Penicillium , Pestalotiopsis , Phoma , Phomopsis , Phyllosticta , and Trichoderma are considered as the predominant producer of the most notable bioactive secondary metabolites [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.

et al. 2020

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Two new polyketides, cytospyrone (1), cytospomarin (2), together with three known metabolites dimethoxyphtalide (3), integracin A (4) and integracin B (5), were isolated from the culture of Cytospora sp. from the Chinese mangrove Ceriops tagal. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound 2 displayed weak inhibitory activity against Escherichia coli GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds 4 and 5 displayed significant cytotoxicity against human cancer cell line HepG2 (IC50 values of 5.98 ± 0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC50 value of 43.50 ± 3.69 µM).

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Lead Compounds from Mangrove-Associated Microorganisms

Cited by 64 publications

References 94 publications

Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1

Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.

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