Lead and lead–arsenic combined exposure induces mortality and developmental impairments in zebrafish embryos: a study using wild-caught zebrafish from Bangladesh

Toma, Nusrat Jahan; Anwar, Saeed; Kabir, Tamanna

doi:10.1080/01480545.2021.1996594

Cited by 6 publications

(1 citation statement)

References 51 publications

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“…To date, a combination of Pb and As exposure has been identified as causing anxiety-like behavior and impairing spatial memory and learning in mice [ 37 ]. Although relevant studies on the compound toxic effects of Pb and As on zebrafish development were carried out [ 38 , 39 ], there is still much room for the exploration of other toxicities. On the other hand, since the nervous system is more sensitive to heavy metal pollutants compared to other organs, single heavy metals all show strong neurotoxicity [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish (Danio rerio)

Liu,

Deng,

et al. 2024

Toxics

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Lead (Pb) and arsenic (As) are commonly occurring heavy metals in the environment and produce detrimental impacts on the central nervous system. Although they have both been indicated to exhibit neurotoxic properties, it is not known if they have joint effects, and their mechanisms of action are likewise unknown. In this study, zebrafish were exposed to different concentrations of Pb (40 μg/L, 4 mg/L), As (32 μg/L, 3.2 mg/L) and their combinations (40 μg/L + 32 μg/L, 4 mg/L + 3.2 mg/L) for 30 days. The histopathological analyses showed significant brain damage characterized by glial scar formation and ventricular enlargement in all exposed groups. In addition, either Pb or As staining inhibited the swimming speed of zebrafish, which was enhanced by their high concentrations in a mixture. To elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (AChE) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, HPI axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. The observations suggest that combined exposure to Pb and As can cause abnormalities in swimming behavior and ultimately exacerbate neurotoxicity in zebrafish by interfering with the cholinergic system, dopamine and 5-hydroxytryptamine signaling, HPI axis function as well as neuronal development. This study provides an important theoretical basis for the mixed exposure of heavy metals and their toxicity to aquatic organisms.

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Section: Introductionmentioning

confidence: 99%

Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish (Danio rerio)

Liu,

Deng,

et al. 2024

Toxics

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Serum Cu, Zn and IL–1β Levels May Predict Fetal Miscarriage Risk After IVF Cycles: A Nested Case–Control Study

Zhang

et al. 2023

Biol Trace Elem Res

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The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

Zhao,

Chen,

et al. 2024

Ecotoxicology and Environmental Safety

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Lead and lead–arsenic combined exposure induces mortality and developmental impairments in zebrafish embryos: a study using wild-caught zebrafish from Bangladesh

Cited by 6 publications

References 51 publications

Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish (Danio rerio)

Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish (Danio rerio)

Serum Cu, Zn and IL–1β Levels May Predict Fetal Miscarriage Risk After IVF Cycles: A Nested Case–Control Study

The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

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