Lead and Cadmium assay in Serum and Semen of Infertile Men attending Andrology clinic in Assiut University Hospital (Rural versus Urban)

Saleh, Medhat A.

doi:10.9790/2402-0243845

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…On the other hand, as it can be observed in Fig. 2, Cd concentrations measured in this study were comparable to those reported in population from Egypt (Saleh et al 2013) and Japan (Katayose et al 2004), and higher than Cd levels measured in people of USA (Pleban and Mei 1983), Singapore (Xu et al 1993), and Kuwait (Omu et al 1995), etc. In this study, high concentrations of Cd in seminal plasma of Pakistani population may be related to the extended industrial and agricultural activities.…”

Section: Cadmium (Cd)supporting

confidence: 92%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p < 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = -0.26, -0.29) and motility (r = -0.33, -0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.

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Section: Cadmium (Cd)supporting

confidence: 92%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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“…The mixture was analysed by atomic absorption spectrophotometer (GBC 933 plus), with air-acetylene flame and hollow cathode lamp (Medhat et al, 2013). Serum Mg and Zn concentrations were determined by using commercial kits with spectrophotometer (Oladipo and Temiye, 2005).…”

Section: Determination Of the Divalent Ionsmentioning

confidence: 99%

Activity of Phosphatase Enzymes, Concentration of Protein and Divalent Ions in Sheep Sera during different Physiological Status

Zaidan¹

2015

J. Anim. Health Prod.

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| The aim of present study was to investigate the probable effects of the reproductive state on the sera component and enzymes in lactating and pregnant sheep. All the blood tests were carried out in 46 healthy sheep. The animals were divided into three groups: first group (G1; n = 15) pregnant, the second group (G2; n = 16) lactating and third group (G3; n= 15) non-pregnant and non-lactating (control group). The results showed that higher concentrations (P< 0.05) of total protein were determined in the blood of pregnant sheep compared to lactating group sheep. Moreover, the alkaline phosphatase (Alp) activities were higher (P< 0.01) in lactating sheep than pregnant and control group, while higher (P< 0.01) concentrations of acid phosphatase (Acp) activity were determined in sera of pregnant compared to lactating and control sheep. The results further showed the higher (P< 0.05) specific activity of Acp in pregnant compared to lactating and control. The higher (P< 0.05) specific activity of Alp were also determined in sera of lactating compared to pregnant and control. The lowest (P< 0.05) sera Zn+2 and Mg+2 levels in pregnant sheep were observed compared with lactating and control group A. Results of this study showed that values of Acp, Alp activities and total protein could be used as an indicator of pregnancy in sheep. We suggest that pregnancy and lactation periods must be taken into consideration for the true interpretation of sera chemistry and ions status in sheep.

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“…There were some highly significant negative correlations between normal sperm morphology (r -0.55, p<O.00l) and seminal plasma cadmium concentration, and between progressive sperm motility (r -0.66, p<0.001) and seminal plasma cadmium concentration. Overall, this study suggests that infertile men from urban areas are more at risk of exposure to hazardous environmental toxicants like cadmium and this requires special attention in management of those men attending infertility clinics and belonging to urban areas (148).…”

Section: Effect Of CD On Reproductive Hormones and Sperm Parametersmentioning

confidence: 88%

“…This study was done to compare serum and seminal plasma levels of lead and cadmium in rural versus urban infertile men from Assiut governorate in Egypt, and also to detect the correlations of these heavy metals with conventional semen parameters and sperm vitality (148). Fifty eight infertile men were included in this study.…”

Section: Effect Of CD On Reproductive Hormones and Sperm Parametersmentioning

confidence: 99%

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The Effects of Lead and Cadmium on Sperm Parameters Including Sperm DNA Fragmentation of Men Investigated for Infertility

Wijiesekara¹

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Lead and Cadmium assay in Serum and Semen of Infertile Men attending Andrology clinic in Assiut University Hospital (Rural versus Urban)

Abstract: Recently, environmental

Cited by 7 publications

References 18 publications

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Activity of Phosphatase Enzymes, Concentration of Protein and Divalent Ions in Sheep Sera during different Physiological Status

The Effects of Lead and Cadmium on Sperm Parameters Including Sperm DNA Fragmentation of Men Investigated for Infertility

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