Lead, age and aggression in male mice

Engellenner, William J.; Burright, Richard G.; Donovick, Peter J.

doi:10.1016/0031-9384(86)90437-3

Cited by 16 publications

(5 citation statements)

References 35 publications

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“…It has been suggested that electrical shock-induced aggression in rats is accompanied by activation of brain dopaminergic (Baggio & Ferrari, 1980) and cholinergic (Nath, Gulati, Dhawan, Gupta & Bhargava, 1982) and/or by depression of serotoninergic (Valzelli, 1982) and noradrenergic (Bell & Hepper, 1987) mechanisms. Although it has been established that aged animals are less aggressive than young ones (Engellenner, Barright & Dorovick, 1986), there are no data about aggressive behavior in animal model of AD. Our findings indicate that NBM-lesioned rats is less aggressive than controls, which could be explained by neurotranssmision imbalance, mostly by cholinergic mechanisms impairment.…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Adaptive Status in an Experimental Model of Alzheimer's Disease in Rats

Popovic

Jovanova-Nešić

Popović

et al. 1996

International Journal of Neuroscience

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Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.

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Section: Discussionmentioning

confidence: 99%

Behavioral and Adaptive Status in an Experimental Model of Alzheimer's Disease in Rats

Popovic

Jovanova-Nešić

Popović

et al. 1996

International Journal of Neuroscience

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“…1,2 As a result, it has powerful effects on vertebrate behavior, including sensorimotor responses, [3][4][5][6] complex learning tasks, [7][8][9] and social interactions. [10][11][12][13][14][15][16] While many studies examined the behavioral effects of Pb 2 + using post-birth or post-hatch exposures, including during juvenile or adult stages, fewer studies investigated changes in adult behavior due to Pb 2 + exposures only during the earliest periods of embryonic or fetal development. 17,18 Such studies are important in that the effects of juvenile or adult exposures may vary depending on age of exposure or degree of sexual maturation [19][20][21][22] ; developmental exposures, however, have a greater potential for permanent, long-term behavioral changes, [23][24][25] possibly due to Pb 2 + -gene interactions or fundamental changes in neurodevelopment during the earliest stages of organ differentiation.…”

Section: Introductionmentioning

confidence: 99%

Experimental Design Affects Social Behavior Outcomes in Adult Zebrafish Developmentally Exposed to Lead

Weber

Ghorai

2013

Zebrafish

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Lead (Pb(2+)) affects neuronal and endocrine systems that influence social interactions. By providing potential hiding locations, spatial heterogeneity may affect Pb(2+)-induced behavioral outcomes. Therefore, a test chamber was designed into which a refuge could be inserted. The refuge allowed test subjects to escape from the mirror image that stimulated agonistic interactions. Behaviors with a mirror were compared with baseline activity patterns without a mirror. Adult (12-month old) male and female zebrafish, exposed to Pb(2+) (0-10 μM) as embryos (2-24 hours post fertilization), were tested individually for 5 min in each chamber design within 2 h of feeding. Behaviors were evaluated for % time in mirror zone, distance traveled (=activity level), and attacks on the mirror image. When there was no refuge, significant concentration-dependent increases occurred in male % time in mirror zone, activity level, and number of attacks. Increases in these variables were less pronounced in females. When there was a refuge, there were significant differences for males only in activity level and attacks at the higher developmental exposure concentrations; % time in mirror zone followed a similar pattern and level as without refuge. Females displayed Pb(2+)-induced behavioral changes only for attacks on mirror. Since the presence of refuges that is, environmental enrichment, reduced Pb(2+)-induced agonistic behavior in both sexes, experimental spatial design can be considered an important factor when interpreting behavioral outcomes.

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“…The male lead-exposed rats in this same study exhibited significantly shorter latencies to aggression than their nonexposed counterparts, and the lead-exposed rats overall demonstrated an increase in exploratory behavior. Aggressive behavior in lead-exposed mice has been documented by other researchers as well (Engellenner, Burright, & Donovick, 1985;Holloway & Thor, 1986). Many human studies have found that lead increases activity level and aggressive behavior (e.g., Marlowe, Stellern, & Errera, 1982).…”

Section: Animal Studiesmentioning

confidence: 79%