Le virus GB-C ou virus « dit » de l’hépatite G est-il impliqué en pathologie humaine ?

Chams, Vida; Fournier‐Wirth, Chantal; Chabanel, A.; Hervé, P.; Trépo, C.

doi:10.1016/s1246-7820(03)00095-8

Cited by 7 publications

(5 citation statements)

References 175 publications

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“…The 12 million viral reads included canonical hepatitis viruses (HAV, HBV, HCV, and HDV) and additional viruses rarely associated with hepatitis, such as HSV-1 and parvovirus B19 ( Table 2 ). Reads from anelloviruses and/or human pegivirus 1, considered nonpathogenic flora [ 20 , 21 ], were identified in 135 of 151 (89.4%) sequencing libraries.…”

Section: Resultsmentioning

confidence: 99%

“…As the first set of TruSeq libraries used only single-end barcode indexes (vs paired-end barcodes for the NexteraXT libraries), a predetermined threshold of >25 reads and >2% genome coverage was used for assessment of positive viral signatures by mNGS in these single-end barcoded samples given the potential for cross-contamination. Detected reads from viruses of unknown pathogenicity that constitute part of the normal viral flora circulating in blood, such as anelloviruses and human pegivirus 1/GB virus C [ 20 , 21 ], were not considered as causes of ALF (Supplementary Table 6). Manual analyses for bona fide reads corresponding to nonviral pathogens (bacteria, fungi, and parasites) revealed only the presence of known laboratory/environmental contaminants or false-positive identifications due to misannotations in the NCBI NT database.…”

Section: Methodsmentioning

confidence: 99%

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Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

Somasekar

Lee

Rule

et al. 2017

Clinical Infectious Diseases

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

Somasekar

Lee

Rule

et al. 2017

Clinical Infectious Diseases

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“…Previous studies on the worldwide prevalence of HPgV in the HCV population showed a rate of 7% in Spain, 3.2% in Colombia, 10.5% in Brazil, 11% in Thailand, 43.6% in Iran, 31% in Saudi Arabia, 14% in Egypt, and 9% in Morocco [37,38,39,40,41,42,43,44]. In Tunisia, HPgV RNA has been detected in 7.2% of HCV-infected patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown that the influence of HPgV infection on HCV chronic liver disease is controversial [47,48,49,50]. Coinfection with >1 virus may contribute to changes in the evolution of liver disease either negatively or favorably [37]. …”

Section: Discussionmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Pegivirus among High-Risk Populations in Tunisia

Dhifallah

Ayouni²,

Chouiha³

et al. 2016

Intervirology

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Objective: A recently discovered non-A-E hepatitis virus has been designated as human Pegivirus (HPgV). HPgV is prevalent in high-risk groups such as patients with hepatitis C virus (HCV), and it is of interest for patients who are at risk for transmitted infections. The aim of this study was to evaluate the prevalence of HPgV as well as the genotype distribution among patients in the Tunisian population who are infected with HCV and also in multitransfused patients. Methods: A total of 144 patients were screened using RTPCR/nested PCR of the 5′-untranslated region (UTR); 14 cases were sequenced and phylogenetically analyzed. Results: Seven (14.9%) subjects from the multitransfused group and 7 (7.2%) patients infected with HCV, respectively, were found positive for HPgV RNA. Sequencing and phylogenetic analysis of the 14 cases revealed that genotype 2a was the main genotype circulating in Tunisian patients. Genotype 2b was found in the amplified samples of 2 HCV-infected patients. Conclusion: This study enriches the limited data on HPgV prevalence in Tunisia, and shows, for the first time, the molecular epidemiology of the circulating strains in this country.

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“…Este sitio al inicio del genoma le permite interactuar directamente con el ribosoma y modular la traducción del genoma viral. Así mismo, el genoma de HPgV también posee una región no codificante en el extremo 3' (3´UTR), la que no presenta repeticiones de adenina (poli-A) o uracilos (poli-U) 17 .…”

Section: Organización Genómica Y Replicaciónunclassified

Pegivirus humano: Potencial patogénico y riesgo de desarrollo de linfoma no Hodgkin

Arroyave-Ospina

Caicedo

Navas

et al. 2018

Rev. chil. infectol.

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The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified in 1995. HPgV is a lymphotrophic virus, with replication sites in bone marrow and lymphoid tissue, as well as in peripheral blood mononuclear cells (PBMCs). Transmission is through sexual and parenteral routes, and recent estimations suggest nearly 750 million people are infected with HPgV worldwide. Almost 25% of infected individuals can develop persistent infection. Until now, HPgV has been considered a non-pathogenic virus; however, epidemiological studies suggest a potential role in lymphoproliferative diseases, particularly in the development of non-Hodgkin lymphoma (NHL). The evidence of this is controversial and the role of HPgV in lymphomagenesis has not yet been demonstrated. Several studies report a high prevalence of HPgV infection in patients with NHL compared to controls and patients with other hematological diseases. Therefore, analytic studies show that HPgV could be related to an increased risk of NHL development. Conversely, other studies indicate no association between HPgV and NHL, so the role of HPgV in lymphomagenesis is not clear. This review summarizes the main findings related to HPgV's pathogenic potential and association with NHL.

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Le virus GB-C ou virus « dit » de l’hépatite G est-il impliqué en pathologie humaine ?

Cited by 7 publications

References 175 publications

Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

Genotype Distribution and Prevalence of Human Pegivirus among High-Risk Populations in Tunisia

Pegivirus humano: Potencial patogénico y riesgo de desarrollo de linfoma no Hodgkin

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