Le virus corfou: Un nouveau Phlebovirusisolé de phlébotomes en Grèce

Rodhain, F; Madulo-Leblond, G.; Hannoun, C.; Tesh, Robert B.

doi:10.1016/s0769-2617(85)80042-3

Cited by 28 publications

(19 citation statements)

References 7 publications

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“…The massive prevalence of SFSV-NT-Ab observed in our study is not unexpected and is congruent with entomological and human data in the literature: (i) isolation of Corfu virus on the eponymous island from Phlebotomus neglectus [17]; (ii) SFSV IgG detected by IFA in human sera in Northern Greece (Macedonia), Central Greece (Evritania and Larisa), North–Western Greece (Epirus), and Corfu Island; (iii) detection of Chios virus, SFSV-like, in Chios island; (iv) sandfly fever epidemics were reported in Swedish UN soldiers and Greek soldiers in 1984 and 2002, respectively [3–5]; (v) a high attack rate (63%) in tourists hosted in Cyprus for a short period [6]; (vi) a 32% prevalence rate of SFSV IgG in Cyprus native population [7]. In contrast with the two other serocomplexes which display an important range of genetic distance between their respective members, Sicilian virus strains are genetically and antigenically much more closely related [14, 16]; therefore, exposure to different SFSV strains (Italy, Turkey, Cyprus, Greece, Ethiopia) can be measured by using the prototypic Italian strain.…”

Section: Discussionsupporting

confidence: 90%

“…Although the pathogenicity of most of these newly discovered viruses remains unknown, they are sympatric with recognized pathogenic phleboviruses [15–17]. Because several viruses of the same serocomplex co-circulate in various regions, interpretation of seroprevalence studies requires using techniques that hold the capacity to discriminate between these antigenically-related viruses.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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Phleboviruses transmitted by sandflies are endemic in the Mediterranean area. The last decade has witnessed the description of an accumulating number of novel viruses. Although, the risk of exposure of vertebrates is globally assessed, detailed geographic knowledge is poor even in Greece and Cyprus where sandfly fever has been recognized for a long time and repeatedly. A total of 1,250 dogs from mainland Greece and Greek archipelago on one hand and 422 dogs from Cyprus on the other hand have been sampled and tested for neutralising antibodies against Toscana virus (TOSV), Sandfly fever Sicilian virus (SFSV), Arbia virus, and Adana virus i.e. four viruses belonging to the 3 sandfly-borne serocomplexes known to circulate actively in the Mediterranean area. Our results showed that (i) SFSV is highly prevalent with 71.9% (50.7–84.9% depending on the region) in Greece and 60.2% (40.0–72.6%) in Cyprus; (ii) TOSV ranked second with 4.4% (0–15.4%) in Greece and 8.4% (0–11.4%) in Cyprus; (iii) Salehabad viruses (Arbia and Adana) displayed also substantial prevalence rates in both countries with values ranging from 0–22.6% depending on the region and on the virus strain used in the test. These results demonstrate that circulation of viruses transmitted by sand flies can be estimated qualitatively using dog sera. As reported in other regions of the Mediterranean, these results indicate that it is time to shift these viruses from the "neglected" status to the "priority" status in order to stimulate studies aiming at defining and quantifying their medical and veterinary importance and possible public health impact. Specifically, viruses belonging to the Sandfly fever Sicilian complex should be given careful consideration. This calls for implementation of direct and indirect diagnosis in National reference centers and in hospital microbiology laboratories and systematic testing of unelucidated febrile illness and central and peripheral nervous system febrile manifestations.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Phleboviruses have been detected previously in Greece in patients and in sand flies. In 1981, Corfu virus was isolated from sand flies captured in the homonymous island [6], and in 1997 Dobler et al [7] reported a human case of acute TOSV infection in a German 73-year-old woman who had returned from Lavrion, a region 60 km south of Athens, Greece. Additionally, in 2002, a novel Sicilian-like phlebovirus caused a major outbreak of febrile syndrome among the Greek army forces in Cyprus; a virus strain (Cyprus strain) was isolated from a patient's blood sample taken on the first day of the disease [8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibodies to phleboviruses within the sand fly fever Naples virus species in humans, northern Greece

Anagnostou

Papa

2013

Clinical Microbiology and Infection

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Phleboviruses are commonly detected in the Mediterranean region. In order to estimate the seroprevalence to Toscana virus (TOSV) and TOSV-like viruses in the human population in northern Greece, we tested serum samples from 595 apparently healthy individuals aged 1-87 years (median: 45 years) for the presence of TOSV IgG antibodies. A seroprevalence of 11.26% was observed, ranging from 0% to 23.5%. Seropositivity was significantly lower in children and adults <30 years of age. The high seroprevalence (>10%) observed in several prefectures of northern Greece suggests that an important proportion of infections caused by TOSV or TOSV-like viruses may be asymptomatic or mild, and therefore underestimated. Increased awareness of physicians is needed during the summer months, when sand flies are active and have the potential to transmit phleboviruses to humans.

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“…Two other phleboviruses. Corfou and Arbia viruses, have recently been isolated from phlebotomine sandflies in the Mediterranean region [4,5]. There is some crossreaction between different sandflv fever (SF) viruses using serological assays such as complement fixation and indirect immunofluorescence [4,6].…”

Section: Introductionmentioning

confidence: 99%

High prevalence rates of antibody to three sandfly fever viruses (Sicilian, Naples and Toscana) among Cypriots

1991

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SUMMARYNeutralizing antibodies to sandfly fever Naples, sandfly fever Sicilian and Toscana viruses were investigated among 479 sera collected from a normal human population in Cyprus. Antibody prevalence rates of 57%, 32% and 20% were found to Naples, Sicilian and Toscana viruses, respectively. The observed frequency of dual and triple infections was higher than would be expected with a random chance of infection. Antibody prevalence rates were similar for men and women for all three viruses tested, but one of two study sites had significantly higher antibody prevalence to Naples and Sicilian viruses than the other. Individuals with antibodies to both Naples and Toscana viruses had higher antibody levels to Naples virus than those with antibodies to Naples virus only. If the antibody prevalence rates found in this study reflect a history of clinical disease as described in the literature, sandfly fever poses a significant public health problem in Cyprus.

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Le virus corfou: Un nouveau Phlebovirusisolé de phlébotomes en Grèce

Cited by 28 publications

References 7 publications

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Prevalence of antibodies to phleboviruses within the sand fly fever Naples virus species in humans, northern Greece

High prevalence rates of antibody to three sandfly fever viruses (Sicilian, Naples and Toscana) among Cypriots

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