Le transfert des micropolluants organiques dans la chaîne alimentaire Etat et perspectives de recherche

Feidt, Cyril; Grova, Nathalie; Laurent, Claire; Rychen, Guido; Laurent, François

doi:10.1051/ocl.2000.0431

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…Due to their physical and chemical properties they migrate through the food chain into hydrophobic compartments. Thus, they accumulate in lipids at the end of the food chain ( − ). Human exposure to these compounds occurs mainly through the diet.…”

Section: Introductionmentioning

confidence: 99%

Detection of Polycyclic Aromatic Hydrocarbon Levels in Milk Collected Near Potential Contamination Sources

Grova¹,

Feidt²,

Crépineau³

et al. 2002

J. Agric. Food Chem.

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Polycyclic aromatic hydrocarbons (PAHs), mainly formed by incomplete anthropogenic organic matter combustion, are ubiquitous in the environment. To assess milk PAH contamination sources, milk samples were collected from the tank milk at farms located near potential contaminating emission sources such as cementworks, steelworks, and motorways. PAH analyses were carried out by gas chromatography coupled to mass spectrometry. Eight PAHs were identified in milk: naphthalene, acenaphthylene, acenaphthene, fluorene, anthracene, fluoranthene, pyrene, and benzo[a]anthracene. For all potential contaminating sources, these eight PAHs were detected with similar profiles and at low concentrations except for fluorene and naphthalene, for which source-molecule interaction is pointed out.

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Section: Introductionmentioning

confidence: 99%

Detection of Polycyclic Aromatic Hydrocarbon Levels in Milk Collected Near Potential Contamination Sources

Grova¹,

Feidt²,

Crépineau³

et al. 2002

J. Agric. Food Chem.

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“…Cavret et al Polycyclic aromatic hydrocarbons (PAHs) are commonly occurring organic contaminants released in the environment (1)(2)(3). More and more studies have focused on the evaluation of PAH bioavailibility for mammals.…”

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confidence: 98%

In Vitro Intestinal Transfer and Metabolism of Polycyclic Aromatic Hydrocarbons

Cavret

Rychen

Feidt

2004

Polycyclic Aromatic Compounds

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Though polycyclic aromatic hydrocarbon (PAH) transfer through intestinal epithelium seems principally governed by transcellular diffusion, other mechanisms may interfere. Several studies suggest a PAH metabolism via CYP450, particularly in liver, but only few data are available regarding intestinal barrier. This in vitro work aimed at studying PAH metabolism and its consequences on the transfer in the intestinal epithelium according to molecule physicochemical properties. It used 14 C-labeled benzo[a]pyrene, pyrene, and phenanthrene. Medium analysis proved a metabolism in intestinal cells for each PAH. Parallel metabolism appeared to play a positive role in the intestinal transfer of PAHs under different forms: 14 C from benzo[a]pyrene, pyrene, and phenanthrene were respectively transferred 26, 4, and 2 times less when cells were incubated with CYP450 inhibitors. Generally speaking, the faster and the higher a PAH crosses intestinal barrier, the less metabolized it will be.

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“…The hydrophobic character of polycyclic aromatic hydrocarbons (PAH) (n-octanol/water partition coefficients, log K ow >4) and their resistance to biodegradation and elimination give them a tendency to accumulate in food chains (Feidt et al, 2000). Diet is one of the main sources of human and animal background exposure to these pollutants (Vyskocil et al, 2000).…”

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confidence: 99%

Short Communication: Study of Mammary Epithelial Role in Polycyclic Aromatic Hydrocarbons Transfer to Milk

Cavret

Feidt

Roux

et al. 2005

Journal of Dairy Science

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Food would appear to be one of the main routes for animal and human contamination with polycyclic aromatic hydrocarbons (PAH). Many studies have shown the presence of PAH in milk and dairy products, suggesting that these foods can represent a part of this contamination. Our work aimed at defining, in vitro, the mammary barrier role in PAH transfer to milk. MAC T cells were cultivated on permeable filters to measure transepithelial permeability of 14C labeled benzo[a]pyrene (BaP), pyrene (Pyr), and phenanthrene (Phen), which differed in their physicochemical properties. The results showed that only 2 molecules, Phen and Pyr, were able to cross mammary cell layers. Phenanthrene radioactivity appeared more quickly in apical media, and its level after a 6-h exposure was 1.3 times higher than for Pyr and 7.7 times higher than for BaP. These findings suggested that mammary epithelium could play a key role in the selective transfer of PAH from food to milk.

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Le transfert des micropolluants organiques dans la chaîne alimentaire Etat et perspectives de recherche

Cited by 9 publications

References 25 publications

Detection of Polycyclic Aromatic Hydrocarbon Levels in Milk Collected Near Potential Contamination Sources

Detection of Polycyclic Aromatic Hydrocarbon Levels in Milk Collected Near Potential Contamination Sources

In Vitro Intestinal Transfer and Metabolism of Polycyclic Aromatic Hydrocarbons

Short Communication: Study of Mammary Epithelial Role in Polycyclic Aromatic Hydrocarbons Transfer to Milk

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