“…Definitions of failure also varied. Fifteen papers defined it as progression to splenectomy, 15,20,[32][33][34][35]39,41,42,[44][45][46]49,50 three as evidence of ongoing bleeding, 13,37,43 three as requirement for further procedure, 46,48,51 and two provided no definition. 36,38 Failure Rates Twenty-two studies, describing 6415 patients with BSI, directly compared failure rates for those treated with SAE and those treated with NOM alone.…”