Le traitement antituberculeux présomptif est-il licite dans la pleurésie lymphocytaire exsudative inexpliquée au Sénégal ?

Sane, M.; Ba-Fall, K.; Lefèbvre, Nicolas; Mounguengui, D.; Camara, P.; Niang, A.; Bonnichon, A.; Chevalier, B.; Saliou-Mbaye, P.; Debonne, J. M.; Margery, J.

doi:10.1016/s0761-8417(07)92647-4

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…In conclusion, tuberculosis is the leading cause of pleural effusion in our study and it is wise to consider it in a resource limited setups. Empirical therapy with anti tuberculosis chemotherapy in patients with undiagnosed pleural effusion should be taken as a last resort [15]. Laboratory and pathology services have vital contribution for etiologic diagnosis of pleural effusion and it is recommended to strengthen the service in the area [8].…”

Section: Discussionmentioning

confidence: 99%

Pleural effusion: presentation, causes and treatment outcome in a resource limited area, Ethiopia

Mekonnen¹,

Amare²,

Alemu³

et al. 2012

Health

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Back ground: Pleural effusion is a common clinical problem with different causes. Objective: To demonstrate clinical features and outcome of pleural effusion. Methods: Prospective descriptive study was conducted involving 110 patients with pleural effusion admitted to a resource limited hospital in Ethiopia. Results: Males and females were almost equally represented. Cough, fever and weight loss were prominent presenting symptoms accounting 90, 77.3 and 77.3 percent respectively. Right side effusion was the common presentation 50 (45.5%). Forty (37.4%) patients had HIV infection among 107 tested. Tuberculosis was the commonest cause 78 (70.9%) followed by parapneumonic effusion 36 (32.7%) and empyema 27 (24.5%). Malignant pleural effusion was detected only in one patient. Eighty one (73.6%) improved from their illness and 7 (6.4%) died. Lympocytic pleural effusion found to be associated with tuberculosis (OR = 3.942 (1.527 - 10.179), P = 0.005. There were no associations between HIV infection, anemia, elevated ESR and side of pleural effusion with tuberculosis. Conclusion: Tuberculosis was the leading cause of pleural effusion in our setup even though etiologic diagnosis was difficult. Strengthening the laboratory and pathology services in the area is strongly recommended

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Section: Discussionmentioning

confidence: 99%

Pleural effusion: presentation, causes and treatment outcome in a resource limited area, Ethiopia

Mekonnen¹,

Amare²,

Alemu³

et al. 2012

Health

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Activité adénosine désaminase pleurale : un outil de choix pour le diagnostic des pleurésies tuberculeuses dans les pays à haute prévalence

Delacour

Ficko

Bousquet

et al. 2013

Immuno-analyse & Biologie Spécialisée

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Hyporexia and cellular/biochemical characteristics of pleural fluid as predictive variables on a model for pleural tuberculosis diagnosis

et al. 2022

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Objectives: Pleural tuberculosis (PlTB) diagnosis is a challenge due to its paucibacillary nature and to the need of invasive procedures. This study aimed to identify easily available variables and build a predictive model for PlTB diagnosis which may allow earlier and affordable alternative strategy to be used in basic health care units. Methods: An observational cross-sectional study compared PlTB and non-TB patients followed at a tertiary Brazilian hospital between 2010 and 2018. Unconditional logistic regression analysis was performed and a Decision Tree Classifier (DTC) model was validated and applied in additional PlTB patients with empiric diagnosis. The accuracy (Acc), sensitivity (Se), specificity (Sp), positive and negative predictive values were calculated. Results: From 1,135 TB patients, 160 were considered for analysis (111 confirmed PlTB and 49 unconfirmed PlTB). Indeed, 58 non-TB patients were enrolled as controls. Hyporexia [adjusted odds ratio (aOR) 27.39 (95% CI 6.26 - 119.89)] and cellular/biochemical characteristics on pleural fluid (PF) (polimorphonuclear in two categories: 3-14% aOR 26.22, 95% CI 7.11 - 96.68 and < 3% aOR 28.67, 95% CI 5.51 - 149.25; and protein = 5g/dL aOR 7.24, 95% CI 3.07 - 17.11) were associated with higher risk for TB. The DTC constructed using these variables showed Acc=87.6%, Se=89.2%, Sp=84.5% for PlTB diagnosis and was successfully applied in unconfirmed PlTB patients. Conclusion: The DTC model showed an excellent performance for PlTB diagnosis and can be considered as an alternative diagnostic strategy by using clinical patterns in association with PF cellular/biochemical characteristics, which were affordable and easily performed in basic health care units.

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Le traitement antituberculeux présomptif est-il licite dans la pleurésie lymphocytaire exsudative inexpliquée au Sénégal ?

Cited by 3 publications

References 7 publications

Pleural effusion: presentation, causes and treatment outcome in a resource limited area, Ethiopia

Pleural effusion: presentation, causes and treatment outcome in a resource limited area, Ethiopia

Activité adénosine désaminase pleurale : un outil de choix pour le diagnostic des pleurésies tuberculeuses dans les pays à haute prévalence

Hyporexia and cellular/biochemical characteristics of pleural fluid as predictive variables on a model for pleural tuberculosis diagnosis

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