Le syndrome des antisynthétases : à propos de quatre observations et revue de la littérature

Frikha, F.; Saïdi, N.; Snoussi, M.; Salah, Raida Ben; Ayed, Mohamed Ben; Daoud, E.; Hentati, Yosr; Makni, S.; Mnif, Z.; Boudawara, T.; Masmoudi, Hatem; Bahloul, Z.

doi:10.1016/j.pneumo.2012.07.002

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Similarly, anti-synthetase syndrome (ASS), also known as anti-Jo-1 syndrome, is a chronic autoimmune condition [ 7 ]. ASS is associated with the presence of antibodies directed against one of the several aminoacyl-transfer RNA (tRNA) synthetases, the most commonly known being the anti-Jo-1 antibody (anti-histidyl-tRNA synthetase) [ 8 ]. Some of the clinical manifestations associated with ASS include interstitial lung disease (ILD), inflammatory myopathy (PM or DM), inflammatory arthritis, and Raynaud’s phenomenon [ 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Overlapping Autoimmune Syndrome

Evbuomwan,

Ingram,

Saleem

2024

Cureus

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Overlapping autoimmune disorders are used to describe the coexistence of more than one autoimmune disease in the same patient. Mixed connective tissue disease (MCTD) and anti-synthetase syndrome (ASS) are autoimmune diseases that manifest with pulmonary involvement, presenting as persistent dyspnea. The coexistence of both conditions in the same patient is extremely rare. We herein report a case of a 44-year-old female who was diagnosed with MCTD with features of ASS (anti-Jo-1 antibody) in the setting of rheumatoid arthritis (anti-cyclic citrullinated peptide (anti-CCP) antibody), which shows temporary breathing improvement following treatment with corticosteroid and mycophenolate mofetil. However, after the completion of mycophenolate mofetil, she was found to be anti-Jo-1 antibody negative and anti-CCP antibody positive. Our case emphasizes the need to recognize overlapping autoimmune conditions in patients with complex clinical features and presentations with the immediate application of a comprehensive diagnostic approach and tailored treatment strategies. Early diagnosis and aggressive treatment are crucial for achieving remission and preventing organ damage.

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Section: Introductionmentioning

confidence: 99%