Le Questionnaire de Plainte Cognitive (QPC) : outil de dépistage de la plainte des sujets présentant une maladie d’Alzheimer ou un MCI

Thomas‐Antérion, Catherine; Ribas, C.; Honore-Masson, S.; Berne, G.; Ruel, Pierre; Laurent, Bernard

doi:10.1016/s0035-3787(04)70946-7

Cited by 21 publications

(21 citation statements)

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“…Depression and anxiety were assessed using the Hospital Anxiety and Depression (HAD) scale [35]. A cognitive complaints questionnaire (Questionnaire de Plainte Cognitive (QPC) [36, 37]) was employed to evaluate participants’ memory failures and cognitive complaints.…”

Section: Methodsmentioning

confidence: 99%

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

et al. 2017

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BackgroundDuring adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer’s disease (AD) pathology on cognitive impairment in later life. In this study we aimed to investigate whether and how premorbid personality traits interact with cerebrospinal fluid (CSF) markers of AD pathology to predict cognitive performance in subjects with mild cognitive impairment or mild AD dementia and in participants with normal cognition.MethodsOne hundred and ten subjects, of whom 66 were patients with mild cognitive impairment or mild AD dementia and 44 were healthy controls, had a comprehensive medical and neuropsychological examination as well as lumbar puncture to measure CSF biomarkers of AD pathology (amyloid beta1–42, phosphorylated tau and total-tau). Participants’ proxies completed the Revised NEO Personality Inventory, Form R to retrospectively assess subjects’ premorbid personality.ResultsIn hierarchical multivariate regression analyses, including age, gender, education, APOEε4 status and cognitive level, premorbid neuroticism, conscientiousness and agreeableness modulated the effect of CSF biomarkers on cognitive performance. Low premorbid openness independently predicted lower levels of cognitive functioning after controlling for biomarker concentrations.ConclusionOur findings suggest that specific premorbid personality traits are associated with cerebral AD pathology and modulate its impact on cognitive performance. Considering personality characteristics may help to appraise a person’s cognitive reserve and the risk of cognitive decline in later life.

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Section: Methodsmentioning

confidence: 99%

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

et al. 2017

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“…The Hachinski ischemic scale [53] was used to assess vascular risk factors. We administered the Questionnaire de plainte cognitive [55] and the GDS [51] to assess cognitive complaints and depressive symptoms, respectively. We examined episodic memory using the Rappel libre/rappel indicé à 16 items [56], a free/cued word recall test used as a measure of verbal learning in French-speaking populations; the procedure of the Rappel libre/rappel indicé à 16 items is similar to the Free and Cued Selective Reminding Test [57].…”

Section: Methodsmentioning

confidence: 99%

Structural Neuroimaging of Concomitant Depressive Symptoms in Amnestic Mild Cognitive Impairment: A Pilot Study

Morin

Mouiha

Pietrantonio

et al. 2012

Dement Geriatr Cogn Disord Extra

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Late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) can both denote prodromal Alzheimer’s disease. While the two concepts share common clinical features, differential diagnosis between them is crucial. The objective of this pilot study was to explore differences in terms of the hippocampal (HC) and entorhinal cortex (EC) volume reduction between LLD and aMCI patients with (aMCI/D+ group) or without (aMCI group) depressive symptoms. Six LLD, 6 aMCI, and 6 aMCI/D+ participants were assessed using a structural magnetic resonance imaging protocol. Manual segmentation of HC and EC was carried out. The results of volumetric comparisons suggest that the HC was larger in aMCI/D+ and LLD subjects compared to aMCI participants. The left EC mean volume was slightly lower in aMCI/D+ subjects. Power analyses revealed that 36 participants per group would suffice to confirm these findings. Overall, these pilot findings suggest that aMCI can be distinguished from LLD based on cerebral atrophy measures, and that HC and EC atrophy in aMCI varies according to the presence or absence of depressive symptoms.

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“…Depression and anxiety were assessed using the Hospital Anxiety and Depression scale (HAD) (Zigmond and Snaith, 1983). Cognitive complaints questionnaire (Questionnaire de Plainte Cognitive, QPC, (Thomas-Antérion et al, 2004;Thomas-anterion et al, 2004)) was employed to evaluate participants' memory failures and cognitive complaints.…”

Section: Neuropsychological and Functional Assessmentmentioning

confidence: 99%

Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology

Tautvydaitė

Antonietti

Henry

et al. 2017

Journal of Psychiatric Research

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Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta (Aβ), phosphorylated tau (ptau-181), and total-tau (tau)). The Revised NEO Personality Inventory (NEO-PI-R) was administered twice, once to evaluate subjects' current personality and once to assess personality traits retrospectively 5 years before evaluation. Subjects with an AD CSF biomarker profile showed significant increase in neuroticism and decrease in conscientiousness over time as compared to non-AD CSF biomarker group. In regression analysis controlling for global cognition as measured by the MMSE score, increasing neuroticism and decreasing extraversion, openness to experience and conscientiousness were associated with lower Aβ concentrations but not with tau and ptau-181 concentrations. Our findings suggest that early and specific changes in personality are associated with cerebral AD pathology. Concentrations of CSF biomarkers, additionally to severity of the cognitive impairment, significantly contribute in predicting specific personality changes.

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Le Questionnaire de Plainte Cognitive (QPC) : outil de dépistage de la plainte des sujets présentant une maladie d’Alzheimer ou un MCI

Cited by 21 publications

References 0 publications

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Structural Neuroimaging of Concomitant Depressive Symptoms in Amnestic Mild Cognitive Impairment: A Pilot Study

Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology

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